Project Grant R21HD121843
- The National Institute of Child Health and Human Development, part of the Department of Health and Human Services National Institutes of Health, awarded $456,500 to The University of Texas Southwestern Medical Center on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award funds molecular characterization of human pregnancy-induced cervical epithelium through two research aims. First, the recipient will apply single-cell and spatial...
- The National Institute of Child Health and Human Development awarded Boston University (Trustees of Boston University, doing business as Boston University Medical Campus) $702,577 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct a longitudinal study examining heat exposure, placental health, and adverse pregnancy outcomes. The research leverages an existing cohort of 610 pregnant women who attended prenatal visits at...
- The National Institute of Child Health and Human Development awarded the University of Texas Health Science Center at Houston $688,009 on May 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate trophoblast differentiation and placental aging. The award funds research testing the hypothesis that precocious trophoblast differentiation leads to exhaustion of the trophoblast stem cell pool, triggering premature placental aging and...
- The National Institute of Child Health and Human Development awarded the University of Texas Health Science Center at Houston $689,884 on June 1, 2026, for the HUMIDITI Trial, a multicenter randomized controlled trial investigating optimal humidity management in heated incubators for infants born at 22–24 weeks' gestation under the Child Health and Human Development Extramural Research program (CFDA 93.865). The study addresses a critical knowledge gap in neonatal intensive care: despite...
- The National Institute of Child Health and Human Development awarded University of Maryland, College Park $515,009 on August 24, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to quantify the individual and combined effects of extreme heat and wildfire smoke exposure on hypertensive disorders of pregnancy and gestational diabetes mellitus. The research leverages a healthcare claims dataset encompassing approximately 6.5 million births during the...
- The National Institute of Child Health and Human Development awarded the University of Houston System $597,736 on June 9, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct a randomized controlled trial of a scalable web-based parenting program designed to support brain development, autonomic regulation, and socio-emotional development in preterm infants. The study targets parents of preterm infants—those born before 37 weeks of...
- The National Institute of Child Health and Human Development awarded Baylor College of Medicine $149,190 on January 1, 2026, to conduct research on microRNA-290's role in regulating maternal-fetal nutrient exchange during neural tube closure under the Child Health and Human Development Extramural Research program (CFDA 93.865). The research investigates how microRNA-290 expressed in extraembryonic tissues, including the yolk sac, affects nutrient transport to embryos during early pregnancy...
- The National Institute of Child Health and Human Development awarded The University of Texas Southwestern Medical Center $682,848 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate mitochondrial function and quality control in germ cell development and reproductive aging. The award funds basic biomedical research using a novel enforced mitophagy platform to modulate mitochondrial abundance and quality in vivo across specific...
- The National Institute of Child Health and Human Development, part of the Department of Health and Human Services, awarded The Johns Hopkins University $1,176,983 on September 12, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct a cluster randomized trial examining the relationship between periodontal disease and outcomes in small vulnerable newborns. The award addresses neonatal mortality among preterm and small-for-gestational-age infants,...
- The National Institute of Child Health and Human Development, part of the Department of Health and Human Services, awarded Yale University $5,063,609 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate how antiretroviral therapy exposure during pregnancy disrupts immune development and placental function in HIV-exposed uninfected infants. The research will use immunopeptidomics, transcriptomics, and functional co-culture assays...
The National Institute of Child Health and Human Development, part of the Department of Health and Human Services National Institutes of Health, awarded $440,000 to the University of Texas Medical Branch at Galveston on August 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award funds research to evaluate mechanistic pathways through which heat exposure during pregnancy triggers preterm birth, addressing a knowledge gap in understanding heat-induced labor-associated signaling at the feto-maternal interface. The recipient will utilize a humanized microphysiologic multi-organ feto-maternal interface on-a-chip model to profile heat-induced microRNA and proteomic alterations at the placenta-decidua and fetal membranes-decidua interfaces. The work will investigate stress-responsive signaling pathways activated by heat exposure through microRNA-mediated post-transcriptional mechanisms and extracellular vesicle-based signaling. Performance of work occurs at Galveston, Texas. The award runs from August 15, 2026, through July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $440.0k | 8/18/26 |