Project Grant R21HD117239
- This Project Grant award of $999,593.00 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to improve understanding of oxytocin receptor (OXTR) function and dynamics. The key objectives are to quantitatively define the trafficking of the OXTR in uterine smooth muscle (myometrial) cells, including membrane insertion, internalization, and recycling. This...
- The National Institute of Child Health and Human Development (NICHD) awarded a $624,998 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Giner Inc. of Auburndale, Massachusetts. The award will fund the development and validation of an electrochemical assay and point-of-care instrument for highly sensitive, near-real-time perinatal monitoring of oxytocin levels. Oxytocin is a critical neuropeptide hormone for facilitating childbirth and...
- This federal Project Grant award of $418,178 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to provide mechanistic insights into the neurobiological mechanisms by which maternal sensitivity is compromised by postpartum depression. Specifically, the University of Massachusetts (UMass), through its Office of Grant & Contract Administration, will use intersectional viral...
- This federal Project Grant award of $234,000 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the underlying mechanisms driving obesity and metabolic disorders in offspring of obese mothers. The research, conducted by Oregon Health & Science University, aims to leverage a mouse model to elucidate how maternal high-fat diet...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $1,603,292.00 to the University of Virginia to study the impact of cesarean section delivery on the maternal brain's epigenetic and transcriptional state, particularly as it relates to the oxytocin system and risk of postpartum depression. The project aims to investigate how...
- The Project Grant award of $632,928 from the National Institute of Child Health and Human Development's (NICHD) Child Health and Human Development Extramural Research program (CFDA 93.865) supports a research study on the neurodevelopmental, health, and economic outcomes of former very preterm infants randomized to an economic intervention supporting mother's own milk. The award, provided to Rush University Medical Center, will fund the comprehensive research initiative from September 2025...
- This federal Project Grant award of $719,141, awarded on August 11, 2025 by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support a longitudinal study comparing maternal prenatal distress effects between in-vitro fertilization (IVF) donor oocyte/embryo and non-donor oocyte pregnancies. The study aims to rigorously test the developmental origins of health and disease (DOHAD)...
- This federal Project Grant award was provided by the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), to study the determinants of postpartum contraception and inter-pregnancy intervals. The total award amount is $1,371,278.00, with a project period from March 1, 2025 to November 30, 2029. The key objectives of this research project are to examine patient, partner, and provider factors that...
- This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), CFDA 93.865 Child Health and Human Development Extramural Research program, provides $235,803 to Texas A&M Engineering Experiment Station (Tees) to bioengineer an in vitro 3D human myometrium model. The goal is to directly evaluate the kinetics (amplitude, velocity, and duration) of myometrial smooth muscle contraction in response to oxytocin, a synthetic hormone...
- This $760,950 Project Grant was awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research Program (CFDA 93.865). The grant supports research at the University of Michigan to characterize how antibody fragments can modulate the signaling of G-protein coupled receptors (GPCRs), such as the oxytocin receptor and angiotensin II type I receptor, which are important in maternal and fetal health during pregnancy. The...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research Federal Grant Program (CFDA 93.865), aims to investigate the potential impacts of postpartum exogenous oxytocin administration on maternal-neonatal oxytocin signaling and behavior in a translational rat model. The $427,625 award, granted on August 6, 2025, will fund research conducted by The Washington University to: 1) quantify the transfer of exogenous oxytocin from mother to offspring through breast milk using stable isotope-labeled oxytocin and mass spectrometry techniques, and 2) assess the effects of this lactational exposure on oxytocin receptor expression and neuronal activation in the hypothalamus of male and female offspring. This research seeks to provide critical insights into the potential unintended consequences of a widely used obstetric practice for postpartum hemorrhage prevention.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.6k | 8/6/25 |