Project Grant R21HD116079
- The federal Cooperative Agreement award U01HD116463, titled "The Infant Down Syndrome Brain and Behavior Study", is funded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The $2,927,457 award will support a longitudinal study to collect multimodal neuroimaging, cognitive/behavioral data, and social communication measures in a cohort of 100 infants with Down syndrome and 50 typically developing controls. The study aims to...
- The U.S. Department of Health and Human Services, National Institutes of Health (NIH) awarded a $1,017,548 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the University of North Carolina at Chapel Hill. The grant, titled "HOME GROWN: A FAMILY-BASED LIFESTYLE INTERVENTION TO SUPPORT HEALTHY DEVELOPMENT OF YOUNG CHILDREN WITH DOWN SYNDROME," will fund a 2-phase study to evaluate the feasibility (R61 phase) and efficacy (R33 phase) of a tailored healthy...
- This federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $2,357,335 to study neuronal dysfunction in Down syndrome (DS) and its link to Alzheimer's disease (AD). The key products and services delivered under this award include: Utilizing induced pluripotent stem cell (iPSC)-derived cortical organoids and assembloids to examine the cellular, transcriptomic, and motility-related...
- The Project Grant award of $451,000.00 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) is funding research at the University of Texas Southwestern Medical Center (UT Southwestern) to identify genes on human chromosome 21 that contribute to the neurological and developmental impairments associated with Down syndrome. The 2-year project will use CRISPR interference (CRISPRi) technology and induced pluripotent stem cells (iPSCs) derived from individuals...
- The University of California, Davis received a $250,000 Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) to conduct a 3-year longitudinal investigation of expressive communication (EC) development in 180 children with Down syndrome from 18 to 54 months of age. The project will use deep-phenotyping and dense-sampling methods, both in-person and via telehealth monitoring, to enhance understanding of the variability, nature, and...
- This federal Project Grant award of $852,356 from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) will fund "The Synchrony Study: A Randomized Controlled Trial of Music Training for Children" conducted by the Lovelace Biomedical Research Institute. The grant aims to investigate whether music training can improve brain function and targeted skills in children with Fetal Alcohol Spectrum Disorder (FASD) through the framework of...
- This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) is providing $661,575 to Children's Hospital Los Angeles to conduct a 5-year study on Down Syndrome Regression Disorder (DSRD). The principal investigator, Dr. Jonathan D. Santoro, is an international expert on DSRD, a neuropsychiatric condition in individuals with Down Syndrome that causes severe...
- This Project Grant award from the Department of Health and Human Services National Institutes of Health (CFDA 93.310 Trans-NIH Research Support) provides $446,096 to the University of Illinois to develop and implement community-based participatory health research with young adults with Down syndrome. The project aims to reflect the perspectives and lived experiences of adults with Down syndrome, including those from underserved and underrepresented communities, to reduce health disparities and...
- This $5.2 million project grant from the Department of Health and Human Services National Institutes of Health Office of the Director, under the Trans-NIH Research Support program, will fund research at the University of Colorado Denver to study neurovascular dysfunction in individuals with Down syndrome revealed by traumatic brain injury. Over three years, the collaborative multi-principal investigator team will establish how trisomy 21-related cellular defects and candidate genes exacerbate...
- This Project Grant award of $1,303,054 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports research to create new mouse models of Down Syndrome (DS) that better represent the genetic variability seen in humans. The objectives are to identify modifier genes and molecular pathways affecting the variability in skeletal and neurobehavioral traits associated with DS, and determine if improving skeletal defects can ameliorate brain-related...
The Project Grant award of $463,645 from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) will fund a study on the effects of drumming lessons on brain and behavior in children with Down syndrome (DS). The project, led by Vanderbilt University, will conduct a randomized controlled experiment to assess the impact of drumming lessons on inhibitory control, beat perception, and social behavior in 7- to 12-year-old children with DS. The study aims to determine if drumming lessons can improve inhibitory control and other key skills in this population. The award period runs from September 12, 2025 to August 31, 2027. If the study demonstrates the predicted benefits of drumming, the results could inform new approaches to supporting children with DS and enhancing their quality of life.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $463.6k | 9/11/25 |