Project Grant R01HD114721
- This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $441,250 to the University of California, Davis (UC Davis) to develop and validate a telehealth-delivered expressive language assessment tool for individuals with Down syndrome. The project aims to expand the accessibility and language capabilities of the Expressive Language Sampling-Narrative (ELS-N) procedure, which has shown promise as a psychometrically...
- This Project Grant award from the Department of Health and Human Services National Institutes of Health (CFDA 93.310 Trans-NIH Research Support) provides $446,096 to the University of Illinois to develop and implement community-based participatory health research with young adults with Down syndrome. The project aims to reflect the perspectives and lived experiences of adults with Down syndrome, including those from underserved and underrepresented communities, to reduce health disparities and...
- The federal Cooperative Agreement award U01HD116463, titled "The Infant Down Syndrome Brain and Behavior Study", is funded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The $2,927,457 award will support a longitudinal study to collect multimodal neuroimaging, cognitive/behavioral data, and social communication measures in a cohort of 100 infants with Down syndrome and 50 typically developing controls. The study aims to...
- The National Institute of Child Health and Human Development (NICHD) awarded a $163,813 Project Grant to the University of Colorado-Denver (UCD) for the project "Improving Health Care Communication and Engagement for Adults with Down Syndrome." The 5-year grant, starting on September 3, 2025, aims to address health disparities experienced by individuals with Down syndrome by developing and piloting a patient-and-supporter-driven communication tool tailored for adults with Down...
- The U.S. Department of Health and Human Services, National Institutes of Health (NIH) awarded a $1,017,548 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the University of North Carolina at Chapel Hill. The grant, titled "HOME GROWN: A FAMILY-BASED LIFESTYLE INTERVENTION TO SUPPORT HEALTHY DEVELOPMENT OF YOUNG CHILDREN WITH DOWN SYNDROME," will fund a 2-phase study to evaluate the feasibility (R61 phase) and efficacy (R33 phase) of a tailored healthy...
- This $2,598,199 Cooperative Agreement, awarded by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), will support a multi-center, multi-disciplinary research project titled "Advancing the Lives & Health of Youth and Young Adults with Down Syndrome (ALLY-DS)." The project aims to establish a diverse cohort of individuals with Down syndrome for comprehensive longitudinal phenotyping, including multi-omics data...
- This federal Project Grant award for $152,816.00, provided by the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research), aims to investigate the link between Down's syndrome (trisomy 21) and placentation defects. The research will focus on: Identifying transcriptional differences in implantation-stage trophoblasts between trisomy 21 and euploid induced pluripotent stem cell lines through RNA-sequencing. Assessing the...
- The University of Colorado received a $430,375 Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) on July 17, 2025. The funding will support research to define the association between Down's syndrome (trisomy 21) and placentation defects. The project aims to identify transcriptional differences in trisomy 21 implantation-stage trophoblasts and assess the role of the NRIP1 gene in trophoblast differentiation. This innovative...
- This federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $2,357,335 to study neuronal dysfunction in Down syndrome (DS) and its link to Alzheimer's disease (AD). The key products and services delivered under this award include: Utilizing induced pluripotent stem cell (iPSC)-derived cortical organoids and assembloids to examine the cellular, transcriptomic, and motility-related...
- This Project Grant award, funded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), is focused on investigating the susceptibility of basal forebrain cholinergic neurons in individuals with Down syndrome. The key objectives of this $111,783 award, which runs from November 9, 2024 to June 30, 2026, are to: 1) determine if there are fewer basal forebrain cholinergic neurons and earlier accumulation of Alzheimer's disease pathology in the early...
The University of California, Davis received a $250,000 Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) to conduct a 3-year longitudinal investigation of expressive communication (EC) development in 180 children with Down syndrome from 18 to 54 months of age. The project will use deep-phenotyping and dense-sampling methods, both in-person and via telehealth monitoring, to enhance understanding of the variability, nature, and timing of clinically meaningful EC indicators. The research aims to (1) characterize individual differences at study entry, (2) use deep-phenotyping and dense longitudinal sampling to describe heterogeneity and developmental changes in EC skills, and (3) examine heterogeneity and development across the sample. The award period runs from August 1, 2025 through May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $250.0k | 7/30/25 |