Project Grant R21HD115906
- The Project Grant, awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund a study to investigate how maternal hyperglycemia impacts embryonic metabolism and development in the C. elegans model. The $474,878 award will enable researchers at Childrens Hospital Medical Center to generate single-cell resolution data on metabolic changes during embryonic...
- This Project Grant award of $249,000.00 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to understand the impact of fetal growth restriction (FGR) on the development of non-communicable diseases like cardiovascular disease, hypertension, obesity, and diabetes. The award, with a performance period from July 1, 2025 to June 30, 2028, will...
- The University of Colorado has been awarded a $127,266 Project Grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865). The grant aims to investigate the relationship between embryonic glucose homeostasis and neural tube closure, with a focus on the role of Insulin Receptor Substrate 1 (IRS-1) as a potential factor in the risk of neural tube defects...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), is providing $226,608 to the University of Colorado-Denver to assess the mechanism by which fetal glucagon inhibits placental nutrient transfer. The objective is to identify the link between fetal glucagon and placental nutrient delivery as an adaptive mechanism to match...
- The federal Project Grant award titled "INVESTIGATING PLACENTAL EFA METABOLISM IN GDM THROUGH INTEGRATIVE SPATIAL MULTIOMICS" was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $765,571 award, granted on August 1, 2025, supports research conducted by Oregon Health & Science University (OHSU) to investigate the effects of gestational...
- The University of Colorado was awarded a $140,400 Project Grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) to investigate the functions of lipid homeostasis during neural tube closure. The 2-year grant, awarded on September 1, 2025, will support research to understand how disruptions in lipid regulation impact neural progenitor cell specification, proliferation, and...
- This federal Project Grant award for $168,886 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research by the University of Texas Southwestern Medical Center to elucidate the role of NAD+ and PARP1 in nephron endowment and fetal nephrogenesis. The 5-year project, running from May 2025 to January 2030, aims to study how maternal NAD+...
- This $160,500 Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) supports research to investigate the mechanisms behind reduced sex steroid hormone synthesis in a rat model of lean type 2 diabetes. The research team at Baylor College of Medicine will use their recently developed gestational low-protein diet rat model to examine how mitochondrial dysfunction and altered...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will provide $132,257 to The Trustees of Columbia University in the City of New York to study the impact of maternal glucose fluctuations on fetal behavioral states and autonomic regulation. The project aims to leverage continuous glucose monitoring and other innovative wearable...
- This $163,145 Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the role of microRNAs in placental development and fetal growth restriction (FGR). The principal investigator will model metabolic stress associated with FGR by culturing extravillous trophoblasts in nutrient-restricted media, and analyze the...
The federal Project Grant award of $187,500.00 was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award, titled "BEYOND FOLATE - A SUPPLEMENTATION STRATEGY TO PREVENT NEURAL TUBE DEFECTS", is focused on investigating a novel nutritional approach to prevent structural birth defects associated with maternal diabetes. The research, conducted by the Pennington Biomedical Research Center in Louisiana, aims to explore using downstream metabolites of glucose as a supplementation strategy to relieve the nutritional deficit experienced by embryos exposed to maternal diabetes, rather than directly addressing the excess blood glucose. The project will combine this targeted nutritional approach with measurements designed to reveal the underlying biological mechanisms and inform potential clinical interventions to improve outcomes for pregnancies affected by diabetes. The award period runs from Aug 11, 2025 through Jul 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $187.5k | 8/11/25 |