This federal Project Grant award, valued at $431,750, was provided by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research by Rutgers, The State University of New Jersey, to investigate the mechanistic impact of mutations in the mitochondrial Lon protease on mitochondrial DNA integrity and gene expression. The research employs patient-derived induced pluripotent stem cells to characterize differences in mitochondrial protein turnover, energetics, and cellular stress responses between wild-type and mutant Lon proteins. Additionally, the project will determine mitochondrial DNA binding by these proteins and analyze the biogenesis of mitochondrial RNA transcripts using advanced microscopy techniques. This research aims to provide new insights into the critical role of the Lon protease in regulating mitochondrial DNA maintenance, transcription, and translation, with broader implications for understanding common diseases like cancer, neurodegeneration, and cardiac dysfunction.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $431.8k | 9/11/24 |