The Children's Hospital of Philadelphia (CHOP) has been awarded a $260,887 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) by the National Institute of Child Health and Human Development. The purpose of this 2-year grant, with a performance period from August 2024 to July 2026, is to study the effects of chronic in utero hypoxia on the placenta, brain, and epigenome using rodent models.
CHOP's research team will leverage specialized 4D in utero MRI technology to simultaneously assess structural and metabolic changes in the placenta and fetal brain under normoxic and hypoxic conditions. Additionally, single-nucleus multi-omic sequencing will be used to evaluate the relationship between metabolic dysfunction and disruption of the brain's transcriptome and epigenome. A sub-award to the University of Pittsburgh will support the implementation of the 4D MRI imaging techniques. This research aims to elucidate the complex "placenta-brain axis" and identify novel targets for treating neurodevelopmental deficits associated with chronic prenatal hypoxia.
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