The University of Wisconsin System, through its University of Wisconsin - Madison division, was awarded a $218,265 Project Grant from the National Institutes of Health's National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) to develop a quantitative ultrasound (QUS) imaging technology for detecting cell death in the brains of human neonates. This research aims to optimize QUS data acquisition and analysis to obtain normative data for key QUS features in selected brain regions, and then apply QUS to detect cell death in neonates with brain injury caused by perinatal asphyxia. The research has the potential to enable the study of when and where cell death occurs in infant brains, provide a means of neuromonitoring in critical care, and assist in optimizing clinical treatments.