Project Grant R21EY039618
- The National Eye Institute awarded Illumination Diagnostics, Inc. $319,330 under the Vision Research program (CFDA 93.867) on August 1, 2026, to develop and validate a continuous transpalpebral pupillometer that measures pupil responses through closed eyelids for early detection of brain swelling and visual loss in intensive care and operating room settings. The device addresses two unmet clinical needs: In the ICU, current pupil assessment relies on manual eyelid opening and subjective...
- Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded $417,162 to the University of Houston System for a two-year project (July 1, 2025 – June 30, 2027) investigating the birefringence properties of the lamina cribrosa and posterior eye structures as they relate to glaucoma detection and diagnosis. The project addresses a critical clinical need by developing advanced optical imaging methodologies to detect early structural and stress-related changes...
- The National Eye Institute awarded Emory University $126,530 in project grant funding on August 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the role of ezrin in Schlemm's canal cell mechanobiology in primary open-angle glaucoma. The research addresses how mechanical forces regulate transcellular pore (i-pore) formation in the Schlemm's canal inner wall, a key determinant of aqueous humor outflow and intraocular pressure. Ezrin, a mechano-responsive protein linking...
- The National Eye Institute awarded Carolina Instruments, Inc. $313,927 under the Vision Research program (CFDA 93.867) on July 15, 2026, to develop PUPIL-LIGHT, a wearable platform technology for acquiring high-speed, high-fidelity measurements of saccades, microsaccades, and pupil dynamics in real time. PUPIL-LIGHT uses photoplethysmography techniques with a camera-free design employing lightweight LEDs and sensors to measure pupil dynamics and fine eye movements at high sampling rates...
- The National Eye Institute, National Institutes of Health, awarded $1.234892 million to Intelon Optics, Inc. on September 15, 2025, under the Vision Research program (CFDA 93.867) to develop a next-generation Brillouin Optical Scanner System (BOSS) with improved speed, accuracy, and sensitivity for ocular biomechanics measurement. The project will translate research technology developed by Dr. Scarcelli at the University of Maryland into a commercially viable clinical device capable of detecting...
- The National Eye Institute awarded West Virginia University Research Corporation $146,541 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the interplay of hemodynamic and biomechanical factors in glaucoma pathophysiology using integrated ultrasound imaging methods. The project integrates super-resolution ultrasound localization microscopy with ultrasound elastography strain tracking in a small animal model to examine how systemic and ocular hemodynamics...
- The National Eye Institute awarded the University of Pittsburgh $2,077,596 on September 30, 2025, under the Vision Research program (CFDA 93.867) to conduct electrophysiological and computational research on sensorimotor processing in the oculomotor system, specifically examining how the superior colliculus processes moving targets and generates interceptive saccades. The research addresses gaps in understanding how the nervous system estimates the future location of moving objects to guide...
- The National Eye Institute awarded Legacy Emanuel Hospital & Health Center $702,487 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate pulsatility in retinal and optic nerve head blood flow in glaucomatous disease. The research develops diagnostic tools using scanning laser ophthalmoscopy and laser speckle flowgraphy to measure changes in vessel diameter and blood flow across the cardiac pulse cycle. The project tests two competing hypotheses: whether...
- The National Eye Institute awarded the University of Pittsburgh $433,324 under the Vision Research program (CFDA 93.867) on September 1, 2026, to develop next-generation microfluidic platforms for high-throughput screening of axon growth-promoting compounds as potential regeneration therapies for glaucoma and optic neuropathies. The project focuses on addressing limitations in conventional axon growth assays by engineering microfluidic devices that enable defined chemoattractant gradients,...
- The National Eye Institute awarded the University of Pittsburgh $679,650 on June 1, 2026, under the Vision Research program (CFDA 93.867) to conduct in vivo imaging of the immune response in human uveitis, linking cellular-level optical biomarkers to the immune environment of the living eye. The project will develop and validate adaptive optics ophthalmoscopy (AOO) methods to assess immune responses in posterior uveitis—inflammation affecting the retina and choroid—in real time within living...
The National Institutes of Health National Eye Institute awarded the University of Pittsburgh $403,633 on September 1, 2026, under the Vision Research program (CFDA 93.867) to develop a portable trans-palpebral tonometer (PT-2) for self-administered intraocular pressure measurement in glaucoma diagnosis and management. The research aims to advance a hand-held device based on solitary wave propagation technology that enables patients to self-administer IOP measurements at home without healthcare professional intervention. Preliminary studies demonstrated feasibility using a stack of millimeter spheres in contact with the eyelid, with solitary wave characteristics correlating monotonically to pressure. The R21 grant funds proof-of-concept work to move beyond single-layer proxy and ex-vivo corneal testing toward clinical validation. Current commercial tonometers require professional administration and capture only single-point readings, missing circadian rhythms, sporadic pressure surges, and medication effects that compromise glaucoma diagnosis—an asymptomatic disease accounting for 50 percent of undiagnosed cases in the United States. Performance occurs at Pittsburgh, Pennsylvania. The award period runs through August 31, 2028. The funding is classified as a Project Grant, a mechanism the Vision Research program offers for investigator-initiated research addressing NEI priorities in understanding the eye and visual system and preventing or treating vision disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $403.6k | 8/21/26 |