Project Grant R21EY037867
- This $146,922 project grant award from the National Eye Institute's Vision Research program (CFDA 93.867) supports research at The Johns Hopkins University to understand the chromatin architectural landscape of retinal development at the single-cell level. The project aims to identify how transcription factors manipulate genomic structure to control cell fate specification in the retina, a model system for studying neuronal development. Specifically, the research will use single-cell Hi-C and...
- This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports the development of a novel genetic screening approach termed "Mosaic In Vivo Perturbation (MVP)" to systematically assess gene function in the eye. The $1,387,142 award, effective September 1, 2024 through June 30, 2028, will enable researchers at President and Fellows of Harvard College (Harvard Medical School) to optimize the MVP approach, develop an...
- This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) supports research to understand the relationship between visual feature representation in the inferior temporal cortex and spatial representations in the medial temporal lobe of the primate brain. The $576,474 award to President and Fellows of Harvard College, operating as Harvard Medical School, will utilize innovative neuroimaging and analysis techniques to characterize how visual and spatial...
- This federal Project Grant award for $434,296 was provided by the National Eye Institute (NEI) under the Vision Research grant program (CFDA 93.867) with the goal of studying the neural and computational mechanisms underlying natural viewing behavior in primates, including humans and macaques. The research aims to determine how primates prioritize and guide their visual exploration, and how this is supported by activity in the visual cortex and thalamus. The award recipient, President and...
- The University of Massachusetts Boston received a $435,052 project grant from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to conduct research on the molecular mechanisms that control the spatially precise expression patterns of photoreceptor subtypes for color vision. The long-term goal is to use the Drosophila melanogaster retina as a model to decipher the cis-regulatory mechanisms and identify conserved trans-acting factors that specify...
- This $415,012 Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) supports research to elucidate the competence and fate choice dynamics during retinal development. The University of Colorado-Denver, the awardee, will investigate how the Notch signaling pathway regulates multiple different fate decisions throughout retinal development. This research aims to improve understanding of the probabilistic nature of retinal cell fate specification, which is critical for...
- This federal Project Grant award of $146,922 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research to investigate the role of ankyrins in mediating the development of synaptic connections between photoreceptors and their respective targets in the mammalian retina. The award to Baylor College of Medicine aims to elucidate the early molecular events that coordinate the selective wiring of photoreceptors, which is essential for...
- This Project Grant award for $679,159 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research on in vivo epigenetic reprogramming of retinal ganglion cells (RGCs) in aging mice with glaucoma. The research aims to identify new therapeutic targets for glaucoma that can protect and rejuvenate RGCs, which are specifically targeted and damaged in this disease leading to vision loss. The 4-year project, awarded to The Schepens Eye...
- The National Eye Institute (NEI) awarded a Project Grant of $131,474 to Seattle Children's Hospital, doing business as Seattle Children's Research Institute, with a start date of March 1, 2025 and an ultimate completion date of July 31, 2027. This grant, funded under the NEI's Vision Research program (CFDA 93.867), supports research to elucidate how the microRNA mir9-2 and its distal enhancer regulate the timing of cell fate specification during retinal development. Using in vivo mouse models,...
- The National Eye Institute (NEI) awarded a $448,250 project grant under their Vision Research federal grant program (CFDA 93.867) to The Research Foundation for the State University of New York, operating as Upstate Medical Center. The funding supports a 2-year research project titled "YKI-MITF-ECM Regulation of Eye Progenitor Epithelium Morphology" that will explore the role of the Hippo signaling pathway, the transcription factor MITF, and extracellular matrix in the development...
The National Eye Institute, through its Vision Research program (CFDA 93.867), awarded a $464,750 project grant to President and Fellows of Harvard College, doing business as Harvard Medical School, to support research aimed at understanding how cell lineage contributes to the development of cell diversity in different regions of the chicken retina, including the high acuity area. The project will utilize a new lineage tracing tool called SCRIBBLE to reconstruct lineage "trees" and identify relationships between retinal progenitor cells and their progeny. The research will focus on adapting the SCRIBBLE tool for use with spatial transcriptomics platforms and performing lineage tracing of early retinal progenitor cells in the chicken retina. The project period runs from September 1, 2025 to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/29/25 | ||
| Not listed | $464.8k | 8/15/25 |