The Board of Regents of the University of Nebraska was awarded a $190,538 Project Grant from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), to characterize the use of an improved fluorescent glutamate sensor (iGluSnFR3) to measure glutamate release from rod photoreceptor cells in the retina. This research aims to provide an optical approach for studying synaptic transmission at the first synapse in the visual system, which is critical for the detection of dim light signals. The award has a performance period from January 1, 2025 to December 31, 2026. The findings from this project have the potential to fundamentally change our understanding of how visual information is encoded at the retinal level and enable future investigations by other laboratories on basic and disease-related questions of photoreceptor function.
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