This $243,000 federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), supports research to investigate the role of the SMAD4 protein as a key regulator of extracellular matrix synthesis and degradation in the corneal stroma. The University of Cincinnati will conduct this 2-year study, which aims to elucidate how SMAD4 controls both the TGF-beta-dependent ECM synthesis pathway and the ALK1/SMAD1,5-dependent ECM degradation pathway to maintain corneal stromal morphogenesis and homeostasis. The findings could serve as the basis for improving treatments for corneal ectasia and other ocular diseases. The award date is February 1, 2025, with a completion date of January 31, 2027.
Generated 3/4/25, 5:30 AM