Project Grant R21EY036591

Award Date 9/30/24
Completion Date 9/29/26
Dollars Obligated $428K
Federal Grant Program
93.867
Assistance Type
Project Grant
Place of Performance
Madison, WI 53715, USA
Similar Awards
This Project Grant award from the National Eye Institute (NEI) under CFDA Program 93.867 Vision Research supports a research project focused on understanding the mechanisms underlying successful axonal regeneration in the retinal ganglion cells (RGCs) of the frog Xenopus laevis. The $393,008 award, which runs from January 1, 2025 to December 31, 2029, will utilize live imaging techniques to systematically investigate the intrinsic pathways involving the genes DLK and SARM1, as well as the role...
This Project Grant award from the National Eye Institute (NEI), part of the Vision Research federal grant program (CFDA 93.867), will provide $753,959 to Baylor College of Medicine over the period of June 1, 2024 to May 31, 2029. The project aims to investigate the mechanistic connections between retinal ganglion cell (RGC) activity, resilience, and axon regeneration following traumatic injuries and optic neuropathies like glaucoma. The research will employ cutting-edge approaches to dissect the...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) will support research to elucidate the gene regulatory networks driving neural regeneration in the central nervous system. The overarching objective is to profile changes in gene regulation that cause retinal pigment epithelial (RPE) cells to lose their neural competency as they differentiate. The total funding for this 18-month award is $162,358, with a start date of July 1, 2024 and...
This federal Project Grant award from the National Eye Institute (NEI), under the CFDA 93.867 Vision Research Program, provides funding of $679,159 from May 1, 2025 to April 30, 2029 to The Schepens Eye Research Institute, Inc. to conduct research on in vivo epigenetic reprogramming of retinal ganglion cells in aging mice with glaucoma. The key objectives of this research project are to: (1) investigate the combined effects of aging and elevated intraocular pressure on the development of...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) supports research to elucidate the cellular and molecular mechanisms underlying the protective and regenerative effects of lens injury on retinal ganglion cells (RGCs) following optic nerve crush injury. The $168,396 award to the Regents of the University of Michigan, effective from February 1, 2025 to May 23, 2027, will fund studies to investigate the role of...
This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, under the Vision Research (CFDA 93.867) program, provides $500,500 to support research on the role of retinal ganglion cells in shaping the identity and function of neurons in the superior colliculus visual processing region. The key objectives are to: 1) determine how retinal input influences the morphology and transcriptional profiles of genetically-defined neuron...
This federal Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) is focused on investigating the role of neural activity in improving retinal ganglion cell (RGC) replacement therapies for glaucoma. The $132,597 grant aims to establish a model for manipulating host RGC neural activity to distinguish donor RGC activity and quantify functional integration with existing visual neural circuits. The research will explore how inhibiting host...
The National Eye Institute (NEI) awarded a $477,109 Project Grant (CFDA 93.867 - Vision Research) to the University of Texas Southwestern Medical Center to investigate how the PRDM13 transcriptional regulator influences retinal development and photoreceptor cell fate. The research aims to further the understanding of mammalian retinal development and mechanisms underlying healthy retinogenesis. The project period runs from May 1, 2025 to April 30, 2030. The research will explore how...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), aims to comprehensively dissect the transcriptional control of neuronal positioning and connection formation in the retina. The $393,646 award, with a period of performance from June 1, 2024 to May 31, 2029, will enable researchers at the University of California, Los Angeles (UCLA) to investigate how the transcription factor FEZF1 sequentially regulates the somatic...
This Project Grant award from the National Eye Institute (NEI), with CFDA program number 93.867 (Vision Research), provides $700,098 to the University of Southern California (USC) to conduct large-scale computational modeling and mapping of neural connectivity changes in retinal degeneration. The project aims to create an unprecedented "mesoscale connectivity atlas" of the four stages of retinal degeneration by combining detailed transmission electron microscopy (TEM) reconstruction of...

This federal Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) provides $427,625 to the University of Wisconsin-Madison to define the folate-dependent single-cell methylomic and transcriptomic networks in distinct retinal ganglion cell (RGC) types associated with axon regeneration. The research aims to isolate and analyze regenerating vs. non-regenerating RGCs to identify specific RGC subtypes that contribute to axon regeneration, and evaluate how folic acid supplementation may alter these RGC populations to enhance axon regrowth. This effort could lead to new neuroprotective mechanisms for various neurological disorders affecting the brain, spinal cord, and optic pathway. The project will be conducted over a 2-year period from September 2024 to September 2026.

Generated 5/13/25, 3:32 AM