The National Eye Institute (NEI), through its Vision Research grant program (CFDA 93.867), has awarded a $251,295 project grant to The Research Foundation for the State University of New York to conduct research on the cellular interactions in the optic nerve head in response to mechanical strain and fibrosis related to glaucoma. The objective is to establish an in vitro 3D culture system to study how optic nerve head astrocytes and lamina cribrosa cells signal to each other to produce matrix fibrosis in response to mechanical strain, with a focus on examining the role of the extra domain A isoform of fibronectin and Toll-like receptor 4 signaling. The project will run from May 1, 2024 to April 30, 2026.
Additionally, The Research Foundation for the State University of New York has issued a $345,189 sub-award to the University of Wisconsin System to study the function and role of lamina cribrosa cells as initial mechanosensors in the optic nerve head and the downstream effects leading to increased fibroinflammatory response in glaucoma.
Generated 2/25/25, 5:41 AM