Project Grant R21ES038311
- The National Institute of Environmental Health Sciences awarded the University of Illinois $929,307 on February 18, 2026, under the Environmental Health program (CFDA 93.113) to investigate mechanisms of endocrine disrupting chemical (EDC) induced ovarian damage and female reproductive dysfunction. The recipient will employ single-cell RNA sequencing, spatial transcriptomics, advanced three-dimensional ovarian follicle culture techniques, in vitro and in vivo experiments with individual EDCs and...
- The National Institute of Environmental Health Sciences awarded the University of Cincinnati $698,212 on April 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate the impact of micro- and nanoplastics on cardiac toxicity and heart disease susceptibility. The research addresses mechanisms by which micro- and nanoplastics cause cardiac damage, focusing on mitochondrial dysfunction and oxidative stress in the heart. Preliminary findings show that exposure to micro- and...
- The National Institute of Environmental Health Sciences awarded Wright State University $644,459 on April 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate how polymorphisms in the immunoglobulin heavy chain 3' regulatory region control human antibody production and sensitivity to aryl hydrocarbon receptor ligands. The research addresses a gap between mouse model studies and human biology by creating human B-lymphocyte cell lines to test whether genetic variants in the...
- The National Institute of Environmental Health Sciences awarded $124,107 to the University of Texas at Austin on September 1, 2026, under the Environmental Health program (CFDA 93.113) to conduct research on extracellular vesicles as mediators of epigenetic changes induced by environmental endocrine-disrupting chemicals in male reproductive health. The research investigates how exposure to endocrine-disrupting chemicals modifies epididymosome cargo—specifically small non-coding RNA...
- The National Institute of Environmental Health Sciences awarded The Ohio State University $437,162 under the Environmental Health program (CFDA 93.113) on May 8, 2026, to investigate how obesity-driven production of oxidized linoleic acid metabolites augments lung inflammation following ozone exposure and to test whether reducing dietary linoleic acid intake mitigates this susceptibility in obese populations. The research employs mouse models and human bronchoalveolar lavage and plasma...
- The National Institute of Environmental Health Sciences awarded Emory University $3.9 million on August 21, 2026, under the Environmental Health program (CFDA 93.113) to investigate how early-life environmental exposures influence adult gonadal health and reproductive function. The research uses the Growing Up Today Study, a prospective cohort of 27,706 children enrolled beginning in 1996 and 2004 whose mothers participate in the Nurses' Health Study II. The study will examine cumulative...
- The National Institute of Environmental Health Sciences awarded Duke University $444,125 on February 17, 2026, under the Environmental Health grant program (CFDA 93.113) to develop an integrated computational and experimental workflow for identifying endocrine-disrupting plastic additives using machine learning. The project pursues two aims. Aim 1 develops novel machine learning models trained on publicly available datasets to predict androgen receptor (AR) and estrogen receptor alpha (ERA)...
- The National Institute of Environmental Health Sciences awarded the Board of Regents of the University of Nebraska $249,000 on September 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate roles for oxidative guanine damage in transcription regulation. The recipient, operating through its University of Nebraska Medical Center division in Omaha, Nebraska, will conduct research on how 8-oxoguanine (8-oxog) lesions—oxidative DNA damage arising from reactive oxygen species...
- The National Institutes of Health Office of the Director awarded The Ohio State University $433,125 on July 1, 2026, under the Research Infrastructure Programs (CFDA 93.351) to develop an epitope-tagged estrogen receptor-beta mouse model using CRISPR methodologies that enables unambiguous identification of estrogen receptor-beta protein levels in vivo and characterization of estrogen receptor-beta expression changes in disease models. The project addresses the unreliability of antibodies for...
- The National Institute of Environmental Health Sciences awarded Michigan State University $402,066 on September 27, 2025, under the Environmental Health program (CFDA 93.113) to investigate how the epicardium and the IRE1 signaling pathway mediate the effects of environmental chemical exposure on cardiac function. The project employs three-dimensional human heart organoids derived from induced pluripotent stem cells to model the impact of per- and polyfluoroalkyl substances (PFAS) on lipid...
The National Institute of Environmental Health Sciences awarded Ohio University $404,163 on August 7, 2026, under the Environmental Health program (CFDA 93.113) to survey Type I nuclear receptor activation by environmental toxins, specifically endocrine-disrupting chemicals and nanoplastics. Ohio University will develop and deploy the FLASH-ER assay, a fluorescence-based laboratory method employing bipartite tetracysteine display and biarsenical profluorophore technology to monitor ligand-mediated structural transitions in estrogen receptor ligand-binding domains. The assay tracks how environmental toxins bind to Type I nuclear receptors—including estrogen, androgen, and progesterone receptors—that normally regulate metabolism, development, reproduction, and cell proliferation. The research aims to understand aberrant interactions between endocrine-disrupting chemicals, nanoplastics, and these receptors, which can lead to neurodegeneration, inflammation, autoimmunity, and cancer. The project builds on prior FLASH-ER work examining estrogenic ligands and selective estrogen receptor modulators, and will extend to study ligand-independent transitions in constitutively active estrogen receptor mutants associated with endocrine-resistant breast cancers. Performance occurs in Athens, Ohio. The period of performance runs from August 7, 2026, through August 6, 2028. This is a project grant, the assistance type supporting research by named principal investigators at eligible institutions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $404.2k | 8/6/26 |