Project Grant R21ES037434
- This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) of the National Institutes of Health (NIH), under the Environmental Health federal grant program (CFDA 93.113), supports research on the mechanisms of manganese-induced neurotoxicity via the leucine-rich repeat kinase 2 (LRRK2) protein. The $682,698 award to Florida A&M University (FAMU) aims to investigate how elevated manganese levels, as seen in occupational or environmental exposures, impact the...
- The University of Texas at Austin received a $122,403 Project Grant from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health federal grant program (CFDA 93.113), to conduct research on identifying the neuronal targets and mechanisms of manganese-induced neuromotor disease. The research aims to definitively determine whether manganese primarily targets dopaminergic or GABAergic neurons in the basal ganglia to induce motor deficits. The project will...
- The National Institute of Environmental Health Sciences (NIEHS) awarded a $441,529 Project Grant under the Environmental Health (CFDA 93.113) federal grant program to the University of Georgia Research Foundation, Inc. (UGA Research Foundation) on November 15, 2024. The grant supports research to elucidate the role of epitranscriptomic mechanisms, specifically N6-methyladenosine (m6A) RNA modification, in regulating astrocyte activation and neuroimmune dysfunction induced by chronic exposure...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $1,625,947 to the University of Rochester to conduct research on the relationship between air pollution-derived iron exposure, poverty-related stress, and Alzheimer's disease risk. The key objectives are to evaluate whether ambient and subway-level iron exposure leads to...
- The University of Rochester was awarded a $601,496 Project Grant by the Defense Health Agency under the Military Medical Research and Development (CFDA 12.420) federal grant program. The purpose of the grant is to provide "Mechanistic Insight into the Airborne Hazards Exposure-Related Development of Neurological Disorders." The research conducted under this 3-year grant, from August 1, 2024 to July 31, 2027, will investigate the underlying biological mechanisms by which exposure to...
- This $5,453,538 Project Grant was awarded on September 15, 2025 by the National Institute of Environmental Health Sciences (NIEHS), which administers the Environmental Health federal grant program (CFDA 93.113). The grant was awarded to New York University School of Medicine to investigate the accumulation of micro- and nanoplastic particles in mammalian tissues, including human exposure pathways, tissue deposition, and potential health impacts. Key objectives include quantifying MNP...
- This $414,159 Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the differential stress responses of organelles in eukaryotic cells. The research aims to investigate the molecular mechanisms underlying how cells employ different strategies to respond to nutritional deprivation versus endoplasmic reticulum (ER) stress. The principal investigator at the...
- This Project Grant awarded by the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health federal grant program (CFDA 93.113), aims to biologically validate novel genetic variants associated with increased susceptibility to pesticide-induced Parkinson's disease. The $728,408 award, made on January 17, 2025, will support two complementary research efforts: Evaluating the effects of up-regulating and down-regulating candidate genes on oxidative stress markers in...
- This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health federal grant program (CFDA 93.113), is supporting research to investigate the mechanisms by which exposure to certain chemicals, such as diacetyl and 2,3-pentanedione, can lead to the development of the devastating lung disease bronchiolitis obliterans. The $716,066 award to the University of Rochester aims to determine how these chemical exposures cause stress and...
- The National Institute of Environmental Health Sciences (NIEHS) has awarded a Project Grant under the Environmental Health federal grant program (CFDA 93.113) to the Regents of the University of Michigan, totaling $204,679, with a project period from March 20, 2025 to August 31, 2028. The grant will support research to characterize the risk and protective effects of environmental co-exposures, such as lead (Pb) and psychosocial stressors, on adolescent and young adult cardiometabolic health. The...
The University of Rochester was awarded a $464,133 Project Grant by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health federal grant program (CFDA 93.113) to conduct a study titled "Cell Specific Proteomics Highlights Molecular Signatures of Manganese Neurotoxicity in Dopaminergic Neurons in vivo". The study aims to use the Cell-type Specific in vivo Biotinylation of Proteins (CIBOP) approach to identify proteomic signatures of dopaminergic neurons at different stages of manganese-induced neurotoxicity. The research project will run from August 5, 2025 to July 31, 2027 and is expected to provide key insights into the early and late molecular changes associated with manganese exposure in dopaminergic neurons, potentially leading to the identification of drug targets to modify manganese-induced neurodegeneration.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $464.1k | 8/5/25 |