Project Grant R21ES037201
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Ohio State University $156,080 on February 19, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of NCOA4-mediated ferritinophagy in ozone-induced pulmonary ferroptosis. The research project, scheduled for completion by September 29, 2026, examines the mechanisms by which ground-level ozone (O3) exposure induces lung injury and inflammation through...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded the University of Louisville's Office of Research & Innovation a Project Grant totaling $3,051,769 on September 11, 2025, under the Environmental Health program (CFDA 93.113) to conduct research on RNA modifications in apolipoprotein regulation by environmental exposures. The research project, extending through August 31, 2029, investigates how exposure to polychlorinated biphenyls...
- Federal Grant Award Summary Colorado State University received a $741,154 Project Grant from the National Institute of Environmental Health Sciences under the Environmental Health program (CFDA 93.113), awarded August 1, 2025, and concluding May 31, 2030. The PM2.5 Metals, Oxidative Potential, Exposure, and Risk Assessment (PM OPERA) project investigates how fine particulate air pollution composition and oxidative potential modify health risks associated with cardiorespiratory morbidity and...
- Federal Project Grant Summary Wayne State University received a $1.39 million Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded on June 3, 2025, with a completion date of March 31, 2030. The grant supports research investigating how polyethoxylated surfactants—emerging environmental contaminants found in consumer products such as hard surface cleaners, detergents, paints, and pesticides—disrupt...
- Federal Project Grant Award Summary Emory University received a $1.1M Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded June 18, 2025, with a completion date of March 31, 2030. The award funds the development, testing, and application of novel statistical methodologies to address three critical analytical challenges in environmental epidemiology: (1) incorporating fine spatial resolution exposure...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded the University of Cincinnati $698,212 through the Environmental Health program (CFDA 93.113) on April 1, 2026, to conduct a five-year research project examining the impact of micro- and nanoplastics (MNPs) on cardiovascular health and disease. The project delivers comprehensive research services investigating how environmental MNP exposure causes cardiac toxicity through mitochondrial...
- Federal Project Grant Award Summary The University of North Carolina at Chapel Hill received a $3.08 million Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113) to conduct research on gene-by-environment interactions in respiratory disease. Awarded on September 19, 2025, with a completion date of September 18, 2029, this research initiative will identify genetic and environmental interactions between ozone air...
- Federal Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded the University of Southern California $1,256,897 through the Environmental Health program (CFDA 93.113) on April 10, 2026, for a translational research initiative addressing the health impacts of per- and polyfluoroalkyl substances (PFAS) and metabolic diseases. This eight-year project, extending through March 31, 2034, delivers a comprehensive research program organized into four interconnected...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Ohio State University a Project Grant of $433,125 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct basic research on influenza A virus (IAV) pathogenesis and acute respiratory distress syndrome (ARDS) mechanisms. The two-year research initiative, awarded July 2, 2025, and extending through June 30, 2027, investigates how the viral PB1-F2 protein...
- Federal Project Grant Award Summary The University of Cincinnati's Sponsored Research Services Division received a $459,770 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), effective April 1, 2026, through March 31, 2028. This research initiative will quantify microplastics in house dust samples collected from pediatric participants in the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS), a...
The National Institute of Environmental Health Sciences (NIEHS) awarded The Ohio State University a $437,162 Project Grant (CFDA 93.113 – Environmental Health) on May 8, 2026, for a two-year research initiative examining the relationship between obesity-driven oxidized linoleic acid metabolite (OXLAM) production and ozone-induced lung inflammation. The research will employ mouse models and human biosampling (bronchoalveolar lavage and plasma samples) to investigate whether elevated dietary linoleic acid (LA) intake in obese populations increases circulating polyunsaturated fatty acids and subsequent production of oxalated linoleic acid metabolites—specifically epoxymethyleneoctanoic acids (EPOMEs) and dihydroxyoctadecadienoic acids (DiHOMEs)—that exacerbate respiratory injury following ozone exposure. This project addresses a significant public health gap by developing a precision nutrition strategy to mitigate air pollution vulnerability in obese populations, who represent approximately 42% of the U.S. population. The research tests the hypothesis that reducing dietary LA consumption will decrease lung LA levels and downstream OXLAM production, thereby reducing obesity-exacerbated lung inflammation and injury. The work aligns with NIEHS's mission to investigate how environmental exposures affect biological systems across the lifespan and translate that knowledge into disease-reducing interventions, with research to be conducted at The Ohio State University's Columbus, Ohio facility through May 7, 2028.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $437.2k | 5/11/26 |