Project Grant R21ES037112

Award Date 4/29/25
Completion Date 3/31/27
Dollars Obligated $445K
Federal Grant Program
93.113
Assistance Type
Project Grant
Place of Performance
New York, USA
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The National Institute of Environmental Health Sciences (NIEHS) awarded a $445,240 Project Grant (CFDA 93.113 - Environmental Health) to the Icahn School of Medicine at Mount Sinai to investigate the complex interactions between prenatal metal exposures, gut microbiome composition, and longitudinal telomere length attrition in early childhood. The research aims to identify associations between metal exposure mixtures, susceptible subgroups based on metal-microbiome "cliques," and their influence on biological aging markers from infancy to late childhood. This work is part of a broader effort to better understand the role of environmental factors and the gut microbiome in accelerated biological aging and associated health outcomes across the lifespan. The project will employ advanced statistical methods, including mixture models and interpretable machine learning, to elucidate these intricate relationships using data from a well-characterized pediatric cohort in Mexico City. The findings have the potential to inform targeted interventions focused on preventing adverse health impacts from an early developmental stage through identifying critical windows for metal and microbial modulation.

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