Project Grant R21ES035984
- The U.S. Department of Health and Human Services, National Institutes of Health (NIH) awarded a $167,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to Cedars-Sinai Medical Center to conduct research on "Vascular Niche Restoration to Prevent Delayed Effects of Acute Radiation Exposure (DEARE) in the Hematopoietic System." The project aims to develop therapeutic interventions to restore the bone marrow vascular niche and regenerate long-term hematopoietic...
- The Department of Health and Human Services (HHS) awarded a $554,698 Cooperative Agreement on September 4, 2025 under the Trans-NIH Research Support program (CFDA 93.310) to The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF) to develop angiogenin as a novel radiation medical countermeasure for hematopoietic acute radiation syndrome (H-ARS). The objective is to demonstrate the effectiveness of angiogenin in mitigating radiation injuries and elucidate its...
- The U.S. Department of Health and Human Services' National Institutes of Health (NIH) awarded a $149,008 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. to evaluate PEG-BPEI as a potential mitigator against gastrointestinal acute radiation syndrome (GI-ARS). The project aims to develop a murine model of partial body irradiation that simulates GI injury while sparing a portion of the...
- The National Heart Lung and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), awarded a $587,878 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Texas Tech University System. The 3-year grant, effective September 1, 2025, will support research on the fractionation of red blood cells (RBCs) using label-free magnetophoresis and novel additive-manufactured devices. The goal is to develop techniques to separate healthy, hemoglobin-enriched...
- This Project Grant award of $157,000 was provided by the U.S. Department of Health and Human Services' National Institutes of Health (NIH) through the Trans-NIH Research Support program (CFDA 93.310). The funding supports the development of UTS-1401, a novel small molecule agent, as a medical countermeasure to mitigate hematopoietic acute radiation syndrome (H-ARS) following a radiation mass casualty event. The research, conducted by the collaborative partnership of Henry Ford Health and...
- This federal Project Grant award of $431,750.00 was provided by the National Institute of Environmental Health Sciences (NIEHS), which administers the Environmental Health (CFDA 93.113) federal grant program. The grant is funding research at the University of California, Irvine (UCI) to investigate mechanisms linking DNA damage to the activation of the NF-kB transcription factor and the innate immune response. Specifically, the project aims to identify new signaling pathways that can trigger...
- This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $164,000.00 in funding to Albany Medical College to conduct research on specialized pro-resolving lipid mediators for developing systemic radiation countermeasures. The project aims to address the urgent and unmet clinical need to limit radiation-induced damage in the event of a nuclear incident. Specifically, the research will investigate how pro-resolving lipid...
- This Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program, aims to elucidate how environmental exposures lead to hematopoietic stem cell (HSC) dysfunction and the progression of clonal hematopoiesis (CH). The $560,100 award to the Albert Einstein College of Medicine will investigate whether environmental exposures like pollution and catastrophic events...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), is funded under the Cardiovascular Diseases Research program (CFDA 93.837). The $213,284 award to the Rector & Visitors of the University of Virginia (UVA) supports research to decipher the molecular mechanisms by which systemic iron homeostasis regulates endothelial function and hemoglobin alpha (HBA) expression in the microvasculature. The central hypothesis...
- The National Institutes of Health (NIH) awarded a $222,750 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the University of Alabama at Birmingham (UAB) to support research on defining the molecular targets of arsine gas-induced acute kidney injury. The project aims to elucidate the detailed molecular mechanisms behind the toxic effects of arsine gas exposure, which can lead to hemolysis and subsequent acute kidney injury. The research will utilize a mouse model of...
The National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) Federal Grant Program, awarded a $340,383 Project Grant to The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF) to conduct research on the "Mechanisms of Radiation-Induced Hemolysis". The project aims to investigate the mechanisms underlying red blood cell (RBC) hemolysis following radiation exposure, with a focus on understanding the role of hemoglobin and carbonic anhydrase II oxidation, and the forms of iron released from lysed RBCs. The research, spanning from September 2025 to September 2027, will pursue two specific aims to test the hypotheses that RBC fragility is increased due to hemoglobin and carbonic anhydrase II oxidation, and that free iron and transferrin-bound iron levels are elevated following radiation-induced RBC hemolysis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $340.4k | 9/18/25 |