Project Grant R21EB039177
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded the University of North Dakota $576,649 on July 1, 2026, to develop a miniature transcranial optical imaging system capable of monitoring both neural activity and cerebrospinal fluid movement through an intact skull in freely behaving animals under the NSF Engineering program (CFDA 47.041). The research platform will integrate light-field fluorescence imaging and optical coherence...
- The University of North Dakota was awarded a $419,038 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant, which runs from September 17, 2024 to August 31, 2027, will fund the development of a miniature selective plane illumination fluorescence microscope for high-resolution volumetric imaging in freely behaving mice. This...
- The National Institute of Biomedical Imaging and Bioengineering awarded the Regents of the University of Minnesota $471,967 on May 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award funds development of dual density-dependent molecular AND gates—engineered targeting ligands that selectively bind cells expressing high levels of two distinct antigens via bispecific avidity. The research addresses on-target,...
- The National Institute of Biomedical Imaging and Bioengineering awarded Iowa State University of Science and Technology $215,723 on August 14, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a next-generation, handheld, battery-powered, wireless dual-mode ultrasound-photoacoustic imaging system integrating high-power nanosecond pulsed light-emitting diodes. The project addresses a gap in current imaging...
- The National Institute of Biomedical Imaging and Bioengineering awarded $2.799 million to the University of South Dakota on June 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop engineered mesenchymal stem cells (MSCs) with programmable cellular theranostic capabilities through synthetic biology approaches. The project addresses poor survival and reduced regenerative capacity of MSCs in hostile tissue...
- The National Institute of Biomedical Imaging and Bioengineering awarded the Trustees of Boston University $232,550 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a mid-infrared photothermal fiber probe for label-free imaging and biomolecular composition analysis in endoscopic applications. The project will develop a fiber-based probe that integrates mid-infrared photothermal imaging with...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of North Carolina at Chapel Hill $610,678 on July 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop two innovative short echo-time magnetic resonance imaging technologies for advanced functional MRI applications. The recipient will develop, optimize, and benchmark SORDINO (steady-state on-the-ramp detection of...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Notre Dame $662,737 on March 5, 2026, to develop autonomous hybrid bioprinting technology for hierarchical perfusable vascularized liver tissues under NIH Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286). The project integrates aerosol jet sacrificial printing and extrusion bioprinting methods to construct three-dimensional complex vascular structures with...
- The National Science Foundation awarded a $252,841 project grant to the University of North Dakota's Division of Research & Economic Development to acquire an atomic force microscope. The award period runs from September 1, 2021 through February 28, 2023 under the NSF's Engineering program (CFDA 47.041). The Engineering program seeks to improve quality of life and economic strength by fostering innovation and excellence in engineering research. This particular award will allow the University...
- The National Institute of Biomedical Imaging and Bioengineering awarded Duke University $586,406 under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) on May 1, 2026. The award funds research on immunomodulatory self-assembled peptides (ISAP), a supramolecular biomaterial technology designed to engage natural autoantibodies and modulate immune responses for treatment of chronic inflammatory diseases. The research addresses...
The National Institute of Biomedical Imaging and Bioengineering awarded the University of North Dakota $192,065 on August 15, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a dual-immersion bidirectional light sheet microscopy platform for volumetric imaging across intestinal tissue layers. The project addresses limitations in current imaging tools for capturing dynamic cellular processes in intact intestinal tissue. The developed system integrates dual-sided oblique illumination and detection, adaptive optics for aberration correction, and closed-loop focus control to achieve approximately 2 micrometer lateral resolution to a depth of 300 micrometers. The platform supports both fluorescence and scatter-based reflectance imaging modalities. Engineering and characterization of the DB-LSM system will be validated using standard calibration samples and brain tissue slices, with implementation of a custom imaging chamber to support both explant and intravital preparations. The system's utility will be demonstrated by investigating intestinal macrophage dynamics in tissue explants and live animal models, addressing dysregulation of cross-layer cellular interactions that contribute to inflammatory bowel disease, colorectal cancer, and gut-brain axis disorders. The award recipient is the Division of Research & Economic Development within the University of North Dakota. Work is performed in Grand Forks, North Dakota. The period of performance extends from August 15, 2026, through July 31, 2028. This is a project grant, the assistance type used by NIBIB for hypothesis-, design-, technology-, or device-driven research in biomedical imaging and bioengineering.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $192.1k | 8/13/26 |