Project Grant R21EB037897
- This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), will develop living biosensors to detect and analyze DNA at the single-base level without requiring sample purification or specialized equipment. The $565,614 award will produce a hybrid living biosensor/lateral flow assay that can rapidly detect target DNA sequences,...
- This $447,747 Project Grant award from the National Science Foundation (NSF) Engineering Program (CFDA 47.041) to Trustees of Boston University will develop a novel plasmonic nanosensor system to detect two important classes of RNA molecules - microRNA (miRNA) biomarkers and SARS-CoV-2 viral RNA. The sensor platform uses DNA structures with nanoparticle probes that undergo conformational changes when binding to target RNAs, altering the plasmonic coupling signal which is detected via two-color...
- The U.S. National Institute of General Medical Sciences (NIGMS), through the Biomedical Research and Research Training federal grant program (CFDA 93.859), awarded a $432,834 Project Grant to the Board of Regents of the University of Nebraska on April 15, 2025. The grant supports the development of an "enzyme-free, label-free quantitative microarray technology" to detect and quantify target nucleic acids, such as microRNA, with high sensitivity down to the attomolar (10^-18 M) range....
- This federal Project Grant award, valued at $375,337.00 and provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of photothermal mid-infrared single molecule super-localization microscopy to track the intracellular processes governing mRNA release from lipid nanoparticle (LNP) formulations. The goal is to provide...
- This federal Project Grant award of $459,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop a systematic approach for detecting regulatory RNAs and their functional motifs based on RNA-protein interactions. The key research objectives include: Investigating whether RNA regulates the genomic occupancies of chromatin-associated proteins (CAPs). Employing an...
- This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides $750,000 to Stanford University to develop new technologies for studying RNA, the essential molecules that carry genetic information and play crucial roles in cell functions. The key products and services to be delivered under this 3-year award include: Creating non-destructive methods to directly study RNA localization and interactions within living cells, achieving...
- This $3,000,000 project grant, awarded by the National Science Foundation (NSF) under the Engineering (CFDA 47.041) program, aims to solve the long-standing challenge of developing self-amplifying ribonucleic acid (SARNA) technologies. The project, led by Trustees of Boston University, a private non-profit research university, will: Synthesize a diverse library of modified nucleoside triphosphates (ModNTPs) and use them to produce modified SARNA with extended cellular half-life. Evaluate the...
- This $199,997 federal Project Grant, awarded by the National Science Foundation's Engineering program (CFDA 47.041), aims to improve the stability and sensitivity of a heat-resistant version of the CRISPR-Cas13 enzyme for rapid and accurate detection of disease-causing RNA. The collaborative research project between William Marsh Rice University and its partners will leverage mechanism-based protein engineering and electrochemical devices to generate next-generation RNA detection tools for...
- This $418,043 Project Grant, awarded by the National Institute of Biomedical Imaging and Bioengineering (CFDA 93.286: Discovery and Applied Research for Technological Innovations to Improve Human Health), is funding the development of a self-tunable mRNA gene circuit to precisely control cellular protein levels. The goal is to create a modular, self-adjusting mRNA circuit that can accurately regulate target protein concentrations in cells, addressing challenges with maintaining optimal protein...
- This federal Project Grant award for $390,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of new tools for high-throughput characterization of extracellular RNA, DNA, and vesicles in bodily fluids. The primary objectives are to: 1) develop methods to reliably control for technical variability, RNA degradation, and complexity in cell-free RNA (cfRNA) analysis, including...
The federal Project Grant award of $673,600.00 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to develop an RNA-based sensor that can detect changes in both mRNA and miRNA within living cells and mouse models. The objective is to create a programmable, synthetic biology tool that can identify diseased cells based on their RNA profiles and trigger therapeutic responses, addressing a critical technology gap in the field. The project, awarded to Northeastern University, builds on the institution's expertise in areas such as artificial intelligence, biotechnology, and advanced engineering solutions. This research will leverage large RNA sequencing datasets to precisely pinpoint diseased cells, ultimately enabling more targeted and effective treatments. The project duration is 3 years, from August 1, 2025 to July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $673.6k | 7/28/25 |