Project Grant R21EB037868
- This $220,000 Project Grant award from the National Science Foundation (NSF) under the Computer and Information Science and Engineering (CISE) program supports the development of advanced computational methodologies for drug discovery and development. The primary awardee, the Regents of the University of Minnesota, will create a comprehensive generative AI framework capable of efficiently generating high-quality drug candidates with multiple desired properties. This initiative aims to expedite...
- This $280,000 Project Grant awarded by the National Science Foundation's Computer and Information Science and Engineering (CISE) program (CFDA 47.070) to The Ohio State University aims to develop comprehensive generative AI methodologies and computational tools to expedite drug discovery and enhance cost efficiency. The project seeks to create a holistic generative AI framework capable of generating high-quality drug candidates with multiple desired properties, with the potential to transform...
- This Project Grant award of $404,032 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a machine learning-powered platform for the discovery of peptide ligands for peptide-drug conjugates (PDCs). The key objective is to create a next-generation peptide discovery system capable of identifying PDC leads within 3 months. The platform will utilize a peptide array designed for enhanced protease...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $422,125.00 to the University of Florida to conduct research aimed at "Decoding Enzyme Sequence-Activity Relationships via Generative AI for Rational Enzyme Design." The research program seeks to advance the understanding of enzyme sequence-activity relationships through the application of generative artificial...
- This federal Project Grant award of $590,806 from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program supports research by the Leland Stanford Junior University (Stanford University) to advance structure-based drug discovery. The key focus areas include: Developing machine learning methods to accurately predict a chemical compound's binding affinity to drug targets, leveraging target structure and experimental binding...
- This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop novel high-throughput machine learning approaches to study cell population-wide differences in subcellular object morphology, conformations, and organization using cryo-electron tomography (cryo-ET) data. The $371,427 award, granted on June 10, 2025, will support Carnegie Mellon University in addressing...
- This federal Project Grant award of $798,828.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to discover novel small molecule therapeutics for the safe and effective treatment of opioid use disorder (OUD). The key products and services to be delivered include: The development of an AI platform called M3.AI that will integrate target-based and phenotype-based methodologies to efficiently identify new drug candidates for OUD...
- The National Institute of General Medical Sciences (NIGMS) awarded a $306,872 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Fluid Discovery, Inc., a San Francisco-based biotechnology company, to develop a "Universal Platform for Ultrahigh-Throughput Biocatalyst Evolution with Micro-Mass Spectrometry." The award supports the development of a commercial prototype for Fluid Discovery's novel screening platform, which combines scalable hardware,...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop state-of-the-art software tools capable of accurately modeling bound drug molecules in receptor structures from cryo-electron microscopy (cryo-EM) data with resolutions up to 5-6 Angstroms. The $217,941 award to Molecular Intelligence LLC, a small business, will run from September 1, 2025 to February 28, 2027. This...
- This $254,182 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund the development of a novel, unified X-ray/cryo-EM pipeline for ensemble-based structural refinement. The project aims to address the significant challenges posed by structural disorder, flexibility, and conformational heterogeneity in modern therapeutic modalities, which limit the accuracy of traditional refinement...
This $616,523 federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to advance phenotypic drug discovery (PDD) by developing a generative AI-driven platform for cell morphology-guided, scalable, and controllable small molecule design without relying on drug targets. The key products to be delivered under this 3-year award include: This project will enable a target-agnostic approach to drug design, expanding therapeutic options for diseases without identified drug targets. The award was made to the University of Florida's Division of Sponsored Research on August 8, 2025 with a final completion date of July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $616.5k | 8/7/25 |