Project Grant R21EB037861
- Federal Project Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded the Trustees of Boston University a Project Grant of $613,124 under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) for the period August 15, 2025, through July 31, 2028. The project delivers the development and demonstration of Quantitative Phase Imaging Meta-Sensors (PIMSs)—advanced optical imaging sensors that...
- The National Institute of Biomedical Imaging and Bioengineering awarded Massachusetts General Hospital $247,500 on June 6, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a miniaturized scanning light endoscope with no moving parts for high-speed three-dimensional deep imaging in live biological systems. The recipient will leverage potassium tantalate niobite (KTN) crystal technology to create a compact optical...
- The National Institute of Biomedical Imaging and Bioengineering awarded Trustees of Boston University $641,300 on May 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286, assistance type Project Grant) to develop next-generation chemoproteomic affinity-based peptide probes (CAFBPs) for targeted profiling of oncogenic kinase activity in circulating tumor cells. The project addresses technical barriers in isolating and...
- The National Institute of Biomedical Imaging and Bioengineering awarded Brigham & Women's Hospital Inc. $1,583,125 on May 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a multifunctional interventional device for biopsy and optical imaging-based phase-0 drug response measurements. The recipient will develop an interventional drug response assay (IDRA) device to enable biopsy-based phase-0 measurements...
- The National Institute of Biomedical Imaging and Bioengineering awarded the Trustees of Boston University $245,250 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop living microbial sensors for continuous biochemical monitoring. The project will engineer and validate a self-renewing cell cartridge that maintains bacterial viability for multiple weeks using passive nutrient diffusion and...
- The National Institute of Biomedical Imaging and Bioengineering awarded Northeastern University $219,818 on April 27, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a fully integrated electro-optic sensor for real-time MRI-guided interventions. The award funds development of an interventional device sensor that addresses safety and imaging limitations in MRI-guided procedures. Current active devices for...
- The National Institutes of Health Office of the Director awarded the Trustees of Boston University $1,144,500 on September 4, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop nanobody-based probes that enable precise, multiplexed, and genetically-encoded perturbations to protein conformations and states in human cells. The work will generate a novel class of probes to realize large-scale, unbiased protein interaction mapping through pooled screening methodologies,...
- The National Institute of Biomedical Imaging and Bioengineering awarded Rice University $182,736 on August 3, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a multi-modal, multi-depth, high-resolution micro-endoscope (M3D-HRME) for early cancer detection. The project pursues feasibility studies to create optical micro-endoscopic devices capable of detecting early-stage cancer by combining advances in...
- The National Institute of Biomedical Imaging and Bioengineering, a component of the Department of Health and Human Services National Institutes of Health, awarded $184,063 to the University of Texas at San Antonio on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award funds development of forced-dimerization activated photoacoustic aptamer switch sensors (FDA-PASS), optical probes designed to enable...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB), part of the Department of Health and Human Services National Institutes of Health, awarded the University of Texas at Arlington $339,676 on August 18, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop light-responsive osmium compounds as metallo-reagents for biomedical imaging and photoactivation. The project develops osmium-based...
The National Institute of Biomedical Imaging and Bioengineering awarded the Trustees of Boston University $232,550 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a mid-infrared photothermal fiber probe for label-free imaging and biomolecular composition analysis in endoscopic applications. The project will develop a fiber-based probe that integrates mid-infrared photothermal imaging with fluorescence imaging to characterize protein expression, lipid and nucleic acid composition, and thermal diffusion dynamics in healthy and diseased tissues at sub-micron resolution. The approach combines time-resolved photothermal point-scanning imaging with measurement of thermal diffusion relaxation constants, enabling novel tissue characterization without requiring the stationary benchtop microscopes and sensitive free-space alignment needed by current mid-infrared photothermal technology. The compact, portable fiber probe design offers reduced sensitivity to air humidity and improved signal-to-noise ratio, providing complementary molecular analysis alongside the structural and morphological visualization that clinical endoscopes currently deliver. Performance occurs in Boston, Massachusetts, with a period of performance from September 1, 2026, through August 31, 2028. The award is structured as a Project Grant, an assistance type supporting hypothesis- and technology-driven research in biomedical imaging and bioengineering.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $232.6k | 8/18/26 |