Project Grant R21EB037241
- This $609,250 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Research Infrastructure Programs (CFDA 93.351) will support the acquisition of a new automated multi-run Carbon-11 radiochemistry synthesis system for the Vanderbilt University Institute of Imaging Science's Radiochemistry Core Facility. The new system will augment the facility's existing capacity to manufacture Carbon-11 radiotracers, which are extensively utilized in preclinical...
- This $633,218 project grant awarded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to develop innovative methods for introducing radiolabeled trifluoromethyl groups into molecules for use as positron emission tomography (PET) tracers. The key objectives are to: Develop a general strategy to transform alkyl halides into their corresponding...
- This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the federal Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $174,375.00 to The Johns Hopkins University from December 5, 2024 to November 30, 2027. The project aims to develop new methods for incorporating the radioactive isotope fluorine-18 into complex biomolecules using metal-fluorine bond formation. This will...
- This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of radiofluorination methods and prosthetic groups for rapid construction of PET tracer analogs. The $122,260 award to the University of North Carolina at Chapel Hill will fund research to promote the utilization of quick candidate screening strategies...
- The federal Project Grant award of $1,148,652 was made on April 1, 2025 by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant supports research and development of an ultra-high spatial resolution photon-counting computed tomography (CT) system with multiple focal spots. The key products to be delivered include: Developing system models and...
- This $598,134 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of a novel imaging detector module. The project aims to create an advanced SPECT imaging system that can provide spatial and directional information without rejecting photons, enabling more precise and personalized dosimetry for therapeutic...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to expand the capabilities and streamline the workflow of nuclear magnetic resonance (NMR) spectroscopy for biological research. The $489,500 award, granted on August 1, 2025, supports the development of new methods to extend the size limits of observable systems, improve sensitivity through advanced noise reduction, and...
- This federal Project Grant award for $553,775.00, provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program, supports research to develop a novel photobiocatalysis strategy. The University of California, Santa Barbara is the awardee, with the goal of reprogramming pyridoxal phosphate (PLP)-dependent enzymes as radical enzymes to catalyze...
- This Project Grant award of $708,790.00 was made on July 1, 2025 by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286). The award supports the development and optimization of a modular time-of-flight (TOF) positron emission tomography (PET) prototype scanner at Yale University. The project aims to create a flexible-geometry TOF PET scanner with...
- This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $1,812,356.00 to The University of Texas MD Anderson Cancer Center (MD Anderson) to develop a rapid, inexpensive microfluidics-based approach for dose-on-demand production of human dosage quantities of ready-to-inject radiopharmaceuticals. The project aims to...
This federal Project Grant award of $700,000.00 was made by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award supports research to develop and optimize direct use of [11C]CO2 for reductive methylation to facilitate rapid production of 11C-labeled radiopharmaceuticals. The key goals are to: 1) develop a method for direct use of [11C]CO2 for methylation of heteroatoms, 2) create a site-specific labeling approach using iminophosphoranes and [11C]CO2, and 3) extend the direct [11C]CO2 methylation to carbon nucleophiles. This research aims to provide more reliable and straightforward 11C-labeling capabilities to support advanced molecular imaging applications through Positron Emission Tomography (PET). The award was made to Vanderbilt University Medical Center, a prominent academic medical center, and has a performance period from August 2025 to July 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $700.0k | 8/8/25 |