Project Grant R21EB036735

Award Date 8/1/25
Completion Date 7/31/28
Dollars Obligated $657K
Federal Grant Program
93.286
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
Similar Awards
This is a Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), under the Cardiovascular Diseases Research (CFDA 93.837) program. The $827,682 award will fund a comprehensive research project to develop advanced imaging techniques, including dynamic contrast-enhanced CT, dual-energy CT, and electrical impedance tomography, to characterize pulmonary perfusion and guide personalized treatment of acute respiratory distress...
This Project Grant award from the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop a modern Electrical Impedance Tomography (EIT) device for monitoring children in the Intensive Care Unit (ICU). The $299,900 award to Goodlife Inventors LLC will fund efforts to (1) generate initial designs for an advanced lightweight EIT belt and (2) assess the technical feasibility of a miniaturized, easier to use EIT core device. If...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $144,989 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to The General Hospital Corporation (doing business as Massachusetts General Hospital) to develop, train, and test deep generative models using computed tomography (CT) images to predict lung injury progression and treatment responses in patients with acute respiratory distress syndrome (ARDS). The goal is to leverage artificial intelligence and image...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $1,758,475 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop next-generation in-vivo diffusion MRI (DMRI) technologies. The project aims to overcome key challenges with current DMRI methods, including lack of sensitivity to detect...
This $604,115 federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will support a longitudinal observational study by The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop non-invasive advanced imaging technologies to predict the development of progressive pulmonary fibrosis in individuals with non-idiopathic pulmonary fibrosis interstitial lung...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $185,625 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to develop a novel magnetic resonance imaging (MRI) technology. The technology aims to address the flip angle inhomogeneity problem in high-field 7 Tesla MRI through the...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $1,360,447.52 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop and evaluate an inexpensive, lightweight "brain monitor" device using magnetic resonance imaging (MRI) technology. The goal is to create a portable MRI-based...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the CFDA 93.286 "Discovery and Applied Research for Technological Innovations to Improve Human Health" program, provides $641,063 to develop a dynamic, customizable, vendor-neutral patient projection data library and virtual imaging trial (VIT) software platform (DICOM-CTPD-VIT). This platform will enable the generation of a diverse range of imaging conditions, including...
This $536,954 Project Grant awarded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) will fund research and development of a novel ultra-high-spatial resolution computed tomography (UHR-CT) system using photon-counting detectors and multiple x-ray focal spots. The research aims to overcome limitations of current high-resolution CT systems by developing...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the CFDA program "Discovery and Applied Research for Technological Innovations to Improve Human Health" (93.286), will fund the development of a novel real-time interactive Positron Emission Tomography (PET) and Ultrasound (US) imaging technology. The goal is to enable interactive PET and US scanning with real-time visualization of molecular contrast fused with US images to...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $656,750 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to advance the use of Electrical Impedance Tomography (EIT) for bedside lung perfusion imaging in patients with Acute Respiratory Distress Syndrome (ARDS). The key innovations being developed include adapting EIT for use during regular breathing cycles, utilizing peripheral venous injections instead of central lines, and optimizing image acquisition and post-analysis techniques by leveraging strategies from dynamic contrast-enhanced MRI and CT methods. This research aims to streamline the EIT process and enable safer, more frequent, and precise bedside evaluations of lung perfusion in ARDS patients, ultimately enhancing patient care and clinical outcomes. The project period runs from August 1, 2025 to July 31, 2028.

Generated 8/5/25, 3:04 AM