This $1,230,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will support research on the role of swelling-activated ion channels in immune cell regulation at the University of Chicago. The key objectives are to: 1) Discover and study the function of swelling-activated calcium channels in T lymphocyte maturation and selection, and 2) Investigate the mechanisms of volume-regulated anion...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $231,934 to The Trustees of Columbia University in the City of New York to develop a new modular platform technology that mimics lymph nodes in order to program and expand T cells directly in living systems. The research aims to overcome current challenges in...
This Project Grant award, valued at $574,808, was provided by the National Science Foundation (NSF) through its Engineering program (CFDA 47.041) to Duke University. The project aims to investigate the origins of cellular heterogeneity in T cells, which are critical for immune system function and have applications in cancer therapies like CAR T-cell therapy. The research will leverage advanced technologies, including spatial proteomic multiplexed imaging, in vitro cell tracking, and engineered...
This $295,924 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) aims to develop and demonstrate a high-yield microfluidic device for the enrichment and capture of CD3+ T cells. This device is intended to improve the manufacturing of autologous and allogenic engineered cell therapies such as CAR-T, which currently have time-consuming and costly production processes. The key objectives are to (1)...
The National Institute of General Medical Sciences (NIGMS) awarded a $314,363 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Tango Biosciences Inc. in Chicago, Illinois. The grant supports the development of the Avidimer Platform, a novel phage display-based technology to create affinity reagents and enable high-throughput screening for identifying "molecular glues" - small molecules or biologics that induce proximity between two protein...
This Project Grant award from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) provides $424,734 to the University of Illinois to develop a novel spatial proteomics approach that integrates 3D microscopy techniques with bottom-up proteomic assays. The goal is to create deep proteome profiles of specific immune cells located in different subregions of a tumor. The project aims to 1) develop a workflow for 3D photobleaching-mediated spatial fluorescence encoding of immune...
The National Cancer Institute (NCI), under CFDA 93.396 - Cancer Biology Research, awarded a $449,726 project grant to the University of Illinois to develop tools that enable the rapid analysis of changes in protein interactions within living cells. The project aims to significantly improve the sensitivity and temporal resolution of existing proximity labeling approaches used to map dynamic protein interactomes. Key innovations include engineering biotin ligases that can label proteins with...
The New York University (NYU) School of Medicine was awarded a $1,525,500 Project Grant by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310). The grant funding, which runs from September 1, 2024 to August 31, 2027, supports the development of new technologies to address two major bottlenecks in the chimeric antigen receptor (CAR) T cell therapy development process: identifying tumor-specific antigens and engineering...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,335,099 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) federal grant program to the University of Chicago. The 5-year award, effective September 2, 2024, will support research to identify the genetic instructions and processes that regulate long-distance interactions between enhancers and promoters, which are critical for gene expression control and have implications for human health. The...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop bispecific antibodies (bAbs) fused to interleukin-2 (IL-2), referred to as IL-2 immunocytokines, for the non-invasive and long-lived delivery of Treg-inducing cytokines to the central nervous system (CNS). The $1,714,839 award to the Regents of the University...