Project Grant R21EB036367
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $349,734 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Actiox LLC, a biomedical technology company in Thousand Oaks, California. The project aims to develop a wearable microneedle-based biosensor for continuous, real-time cardiac troponin I monitoring. The goal is to demonstrate the feasibility of this transformative biosensor technology to enable earlier detection of ischemic events and...
- This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $237,827 to Brigham & Women's Hospital Inc. to develop a wearable, non-invasive optical device for continuous blood pressure monitoring in neonates. The device, called CNAP-FlexNIRS, will use near-infrared spectroscopy and photoplethysmography to collect high-resolution pulsatile waveforms and...
- The National Science Foundation (NSF) awarded a $305,000 STTR Phase I project grant to Sensvita Inc. under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The project aims to develop a non-invasive radio frequency sensing technology for home-based monitoring of heart and lung function. The proposed system uses advanced sensing methods to measure critical physiological parameters without the need for skin contact or maintenance, improving the convenience, scalability,...
- The federal Project Grant award, funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop a real-time, continuous monitoring platform to track cardiac troponin I (cTnI) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels alongside electrocardiogram (ECG) readings. The $127,926 award to The Leland Stanford Junior University...
- This $150,000 project grant from the National Science Foundation's Computer and Information Science and Engineering program aims to develop technologies to improve cardiac care for patients in rural and tribal areas of Arizona. Clemson University is partnering with Northern Arizona University and community leaders to plan an integrated remote heart monitoring system. The system will utilize deep learning and Markov-based methods to predict deterioration in symptoms for patients with conditions...
- This federal Project Grant award of $649,678, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports the development of a high-speed, wearable speckle contrast optical spectroscopy (SCOS) system for cuffless blood pressure monitoring. The project aims to convert the existing benchtop SCOS technology into a wearable device capable of multi-hour ambulatory monitoring, and to test the technique in a wider range of subjects,...
- This $500,000 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of the Hemotago HATS-OFF (Hemotag Assessment for Short-Term Outcomes of Heart Failure) technology by Aventusoft LLC, a small disadvantaged business in Boca Raton, Florida. The HATS-OFF system provides a non-invasive, at-home method for long-term monitoring of heart failure patients to detect decompensation early and enable timely therapy...
- This federal Project Grant award of $134,537 from the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop a novel, noninvasive and auto-calibrated pulse-oximetry method that can more accurately and unbiasedly determine a person's arterial oxygen saturation compared to conventional pulse-oximetry. The key products and services to be delivered through this 5-year project include: 1) Theoretical development of the...
- RCE Technologies, Inc. was awarded a $255,892 Small Business Innovation Research Phase I Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program to develop a proof-of-concept machine learning-based diagnostic system for detecting myocardial infarction and ischemia in real-time. The system aims to provide point-of-care clinical classification for heart attack cases using a novel, portable device integrating the awardee's proprietary external...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $295,895 to Ricovr Healthcare Inc. to develop a rapid, low-cost, point-of-care (POC) diagnostic platform for quantitative measurement of placental growth factor (PlGF) to predict and detect pre-eclampsia. The goal is to create an objective, affordable POC tool to improve the clinical diagnosis and monitoring of pre-eclampsia, which...
DEVELOPMENT OF WEARABLE MONITOR TO DETECT DECOMPENSATION IN CARDIAC FAILURE PATIENTS - PROJECT SUMMARY HEART FAILURE IS A CHRONIC CONDITION IN WHICH THE HEART MUSCLE CAN'T PUMP ENOUGH BLOOD TO MEET THE BODY'S NEEDS FOR BLOOD AND OXYGEN. HEART FAILURE AFFECTS OVER 5 MILLION AMERICANS AND IT IS A SERIOUS CONDITION THAT CAN BE LIFE- THREATENING IF LEFT UNTREATED. DECOMPENSATED HEART FAILURE IS THE LEADING CAUSE OF HOSPITAL READMISSIONS IN THE US. A COMMON SYMPTOM OF DECOMPENSATION IS THE DEVELOPMENT OF PERIPHERAL EDEMA. DETECTING EDEMA CAN PROVIDE IMPORTANT CLINICAL INFORMATION TO HEALTHCARE PROVIDERS REGARDING THE SEVERITY OF THE PATIENT'S HEART FAILURE AND HELP GUIDE TREATMENT DECISIONS. HOWEVER, CURRENTLY PATIENTS ARE ASKED TO WATCH FOR EDEMA THEMSELVES BY CHECKING THEIR WEIGHT OR NOTICING SWELLING OF THE LEGS/ANKLES AND SIGNS ARE OFTEN MISSED UNTIL THE LATE STAGES OF DECOMPENSATION. IN THIS CONTEXT THERE IS A NEED FOR A REMOTE MONITOR THAT CAN OFFER AN EARLIER WARNING AND PERMIT TELEHEALTH INTERVENTIONS TO REDUCE HOSPITAL READMISSIONS. USING OUR PREVIOUSLY DEVELOPED FLEXNIRS PLATFORM WE PROPOSE TO BUILD AND VALIDATE A MULTI-WAVELENGTH WEARABLE EDEMA AND MICROCIRCULATION MONITOR AND CONDUCT A PILOT CLINICAL TRIAL IN PATIENTS ADMITTED DUE TO DECOMPENSATE CARDIAC FAILURE IN WHICH WE WILL SEEK TO DEMONSTRATE THAT PHYSIOLOGICAL PARAMETERS RELATED TO RE-COMPENSATION CAN BE FOLLOWED NON-INVASIVELY AND THUS SUPPORT THE FUTURE CONDUCT OF LARGER SCALE STUDIES OF AT HOME MONITORING TO DETECT DECOMPENSATION.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $225.5k | 6/30/25 | ||
| Not listed | $0 | 5/8/25 | ||
| Not listed | $0 | 5/8/25 | ||
| Not listed | $187.9k | 6/26/24 | ||
| Not listed | $187.9k | 6/26/24 |