Project Grant K99HL181290
- The National Heart Lung and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $707,410 project grant to Duke University to address inequities in pulse oximetry related to skin tone. The "Overcoming Inequities in Pulse Oximetry Through Clinical Informatics (OPTIC)" project aims to develop machine learning models to predict which patients are at high risk for "hidden hypoxemia" and identify those who would benefit from...
- This federal Project Grant award of $234,000.00 was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to test the hypothesis that darker skin pigmentation is associated with increased bias in pulse oximeter performance. The project aims to prospectively determine the effects of directly measured skin pigmentation on pulse oximeter accuracy, as current studies rely on subjective race and ethnicity measures which are poor...
- This Project Grant award from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), aims to develop and validate correction algorithms to improve the accuracy of pulse oximeters and temporal thermometers for patients with acute respiratory failure. The $584,575 award to Emory University will quantify the role of melanin in infrared device errors, and use structural equation modeling to create innovative correction...
- This federal Project Grant award of $649,678, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports the development of a high-speed, wearable speckle contrast optical spectroscopy (SCOS) system for cuffless blood pressure monitoring. The project aims to convert the existing benchtop SCOS technology into a wearable device capable of multi-hour ambulatory monitoring, and to test the technique in a wider range of subjects,...
- This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), is focused on developing a next-generation photoacoustic computed tomography device for non-invasive monitoring of brain oxygen metabolism. The $249,000 award, spanning July 2025 to June 2028, aims to design, fabricate, and validate a handheld photoacoustic imaging device that...
- This $200,000 Project Grant awarded by the National Science Foundation (NSF) Division of Electrical, Communications and Cyber Systems under CFDA 47.041 (Engineering) aims to develop and implement a novel testing platform to evaluate the accuracy of wearable photoplethysmography-based blood pressure monitoring devices. The University of Maryland, College Park will construct a bench flow phantom that simulates physiologically relevant blood pressure, blood flow, anatomical, and optical...
- This $449,598 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) aims to develop a novel wireless, noninvasive optical e-tattoo capable of continuously and simultaneously monitoring arterial and venous oxygenation. The key innovations include: (1) an ultrathin, stretchable e-tattoo with an array of photoplethysmography sensors over major artery-vein pairs; (2) algorithms to separate arterial and venous pulses and convert absorbance data into...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), is for the "Development of Integrated OCT/US/PAT System for Intravascular Imaging". The $617,366 award is being used to develop a multimodal intravascular imaging system incorporating optical coherence tomography (OCT), ultrasound (US), and photoacoustic tomography (PAT) technologies. The objectives are to design and construct a confocal...
- This Project Grant award of $807,067.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support a study to pioneer the quantitative documentation of human respiratory kinematic profiles. The study aims to address a critical gap in contemporary physiological monitoring - the inability to quantify labored breathing, which contains vital prognostic information not captured by conventional monitoring. Building on a recent innovation called ARK...
- The federal Project Grant award of $731,827 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) is supporting research conducted by the J. David Gladstone Institutes in San Francisco, CA to investigate the mechanisms of oxygen toxicity. The key objectives include: 1) testing whether specific molecular pathways (diphthamide synthesis, de novo purine synthesis, and mitochondrial electron transport chain) are necessary and sufficient for impaired cell...
This federal Project Grant award of $134,537 from the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop a novel, noninvasive and auto-calibrated pulse-oximetry method that can more accurately and unbiasedly determine a person's arterial oxygen saturation compared to conventional pulse-oximetry. The key products and services to be delivered through this 5-year project include: 1) Theoretical development of the person-specific pulse-oximetry method, including an inverse model to recover finger optical properties and spatial mapping of pulsatile hemodynamics; 2) Prototyping and fabrication of a custom wearable device to implement this pulse-oximetry technique; and 3) Clinical testing and evaluation of the device and method against gold-standard arterial saturation measurements. The goal is to create an equitable, non-biased assessment of arterial oxygen perfusion that addresses potential skin-tone biases in conventional pulse-oximetry methods.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $134.5k | 9/4/25 |