This $178,376 Project Grant award from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) aims to identify and refine novel retinal biomarkers for early detection of Parkinson's disease (PD). The research project, taking place at the University of Wisconsin-Madison, has two key objectives: In Aim 1, the study will use advanced in vivo retinal imaging techniques, including adaptive optics scanning laser ophthalmoscopy (AOSLO), optical coherence...
This National Science Foundation (NSF) Engineering program project grant, awarded under CFDA 47.041, will develop an integrated framework to study the neural connections between visual hallucinations and motor function impairments in Parkinson's disease (PD). The total award amount is $463,693, with a project duration from September 1, 2024 to August 31, 2027. The project will leverage virtual reality, electroencephalography (EEG), and functional near-infrared spectroscopy (fNIRS) to investigate...
This $580,654 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the CFDA 93.286 "Discovery and Applied Research for Technological Innovations to Improve Human Health" program supports the development of a novel interferometric diffuse optics (IDO) system to quantitatively and specifically measure cerebral blood flow. The project aims to create a 1064 nm IDO system that leverages coherence engineering to provide time-of-flight...
This federal Project Grant award, issued by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $466,125 to New York University School of Medicine to conduct research on the neural substrates of the long-duration response in Parkinson's disease. The research aims to uncover the mechanisms underlying the long-term benefits and context selectivity of using...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $472,695 to 3D Bioanalytix, Inc., a woman-owned small business located in San Diego, CA, to develop a blood-based diagnostic test for detecting neurodegenerative diseases such as Alzheimer's and Parkinson's. The project aims to utilize a novel Covalent Protein Painting (CPP) technology platform to identify and differentiate the misfolded protein aggregates that characterize these...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $293,588 to Iris Kinetics Inc. to develop a new multi-spectral light source called the "Effective Uniform Color-Light Integration Device (EUCLID)". The primary goal is to validate EUCLID's impact on multispectral imaging applications, specifically for...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Brainstorm Therapeutics, Inc. aims to develop and validate a novel Parkinson's disease drug discovery platform using patient-derived midbrain organoids. The platform will guide therapeutic candidate identification, patient selection, and trial endpoint refinement to accelerate the development of effective disease-modifying Parkinson's treatments. Key innovations...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) supports research to determine whether micro-stimulation of neurons in the visual cortex can generate perceptions of 3D object shape. The $232,500 award to The Johns Hopkins University will combine electrophysiology, stimulation, and behavioral experiments in macaque monkeys to test the hypothesis that activating neurons in the V4 region encoding 3D geometric shape fragments can bias visual perception. The...
The Project Grant award R01EY036089, funded by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), supports research to investigate the effects of stimulating the nucleus basalis of Meynert on the activity of neurons in the prefrontal and parietal cortices during visual working memory tasks in monkeys. The $666,276 award, with a performance period from January 1, 2025 to December 31, 2029, aims to understand the neuronal mechanisms by which cholinergic stimulation...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will support research to identify progression subtypes of Parkinson's disease (PD) and discover potential drug targets. The $684,451 award to Weill Medical College of Cornell University will enable an integrative analysis of longitudinal clinical, transcriptomic, and...