This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), is supporting research to develop mitochondrial-targeting exosomes (MTEs) containing anti-inflammatory microRNAs (MTE-miRNAs) to treat neuroinflammation. The $469,500 award to Michigan Technological University aims to restore mitochondrial function, reduce oxidative stress, and modulate neuroinflammatory responses in animal models, with the goal of informing future human studies. Key objectives include preparing and evaluating the MTEs, assessing the impact of different dosages on reducing neuroinflammation in rats, and evaluating the effectiveness of the MTE-miRNA treatments over time. The project also focuses on training students in exosome-based therapy and its potential applications in treating neuroinflammatory disorders.