Project Grant R21DK146753
- The National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health within the Department of Health and Human Services, awarded $5.296987 million to the Regents of the University of Minnesota on September 16, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The recipient will investigate HIV reservoir dynamics and their association with metabolic complications in people with HIV on antiretroviral...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded the University of Illinois $882,709 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate adipose tissue dysfunction in simian immunodeficiency virus (SIV)-infected rhesus macaques treated with combination antiretroviral therapy (cART). The research addresses lipodystrophy and metabolic complications that affect over 75% of chronic HIV...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Northwestern University $811,941 on September 3, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop three-dimensional intestinal organoid models that investigate the bidirectional relationship between HIV transcription and intestinal barrier function in people living with HIV. The research uses complementary organoid platforms: patient-derived organoids isolated...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Texas Biomedical Research Institute $905,998 on September 1, 2026, to investigate epigenetic mechanisms driving intestinal epithelial dysfunction in people living with HIV receiving antiretroviral therapy, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research examines how aberrant DNA methylation and altered chromatin accessibility in colonic epithelium contribute...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Baylor College of Medicine $200,000 on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, assistance type Project Grant). The funded research investigates how proteostatic stress—arising from fever-range hyperthermia, altered oxygen tension, and modulation of protein quality control pathways including chaperones, proteasome activity, autophagy, and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Chicago $123,000 on June 16, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to characterize adipocyte heterogeneity and response to metabolic stress. The funded research uses single-nucleus RNA sequencing and a humanized mouse model to investigate how diverse stimuli influence white adipocyte development and specification, with emphasis on...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Northwestern University $794,032 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate mechanisms of intestinal barrier dysfunction in people living with HIV on antiretroviral therapy and to evaluate restoration of the glycan A1,2-fucose as a therapeutic intervention. The research addresses persistent gut leakiness and microbial translocation in...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Arkansas for Medical Sciences $717,457 on February 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate metabolic rewiring of T cells and the pathogenic connection between diabetes and hypertension. The research examines immune-metabolic crosstalk in the progression from type 2 diabetes to hypertension using a high-fat diet-induced...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Beckman Research Institute of The City of Hope $280,232 on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to fund research on gut-fat crosstalk in metabolic regulation. The award supports basic and translational research investigating intestinal mTOR signaling and its effects on white adipose tissue browning, glucose homeostasis, and energy metabolism....
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Tennessee $639,022 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Assistance Type: Project Grant). The award funds a one-year research study designed to promote HIV-to-HIV kidney transplantation as standard-of-care clinical practice in the new regulatory environment following November 2024 modifications to transplant eligibility...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Baylor College of Medicine $240,000 on August 27, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop preclinical mouse models expressing HIV proteins that replicate metabolic comorbidities observed in persons living with HIV, including obesity, cardiovascular disease, chronic kidney disease, osteoporosis, cancers, frailty, and cognitive decline. The research directly responds to funding opportunity PAR-25-068, which encourages cellular and molecular characterization of HIV reservoirs in adipose tissue. The project will combine findings from mouse experiments to characterize organ-specific changes that drive chronic metabolic disorders in HIV-positive populations and provide research tools for the broader field to understand mechanisms underlying heterogeneous metabolic dysfunction in the post-antiretroviral therapy era. The work is performed in Houston, Texas, with a period of performance extending through July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $240.0k | 8/27/26 |