Project Grant R01DK149864
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Northwestern University $811,941 on September 3, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop three-dimensional intestinal organoid models that investigate the bidirectional relationship between HIV transcription and intestinal barrier function in people living with HIV. The research uses complementary organoid platforms: patient-derived organoids isolated...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Tulane University $840,005 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of aryl hydrocarbon receptor (AHR) signaling in intestinal barrier function and inflammation during antiretroviral therapy-suppressed simian immunodeficiency virus infection. The research defines how gut AHR signaling preserves epithelial barrier...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Texas Biomedical Research Institute $905,998 on September 1, 2026, to investigate epigenetic mechanisms driving intestinal epithelial dysfunction in people living with HIV receiving antiretroviral therapy, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research examines how aberrant DNA methylation and altered chromatin accessibility in colonic epithelium contribute...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $127,206 to The Washington University on April 5, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research investigates Prevotella copri-mediated effects of dietary glycan supplementation on microbial community and host metabolism in the context of treating childhood undernutrition. The work builds on clinical trial evidence that microbiota-directed complementary...
- The National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health within the Department of Health and Human Services, awarded $5.296987 million to the Regents of the University of Minnesota on September 16, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The recipient will investigate HIV reservoir dynamics and their association with metabolic complications in people with HIV on antiretroviral...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Regents of the University of California, San Francisco $194,076 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds a multi-omic investigation of the gut-liver axis in HIV-related liver disease. The project will define mechanistic and biomarker pathways along the gut-liver axis that contribute to and predict hepatic fibrosis in people...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Chicago $770,995 on February 2, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of intestinal epithelial heat shock protein 25/27 in mucosal healing following inflammatory injury of the bowel. The research addresses mechanisms underlying mucosal restitution in inflammatory bowel disease, ischemic colitis, and radiation-induced...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Baylor College of Medicine $240,000 on August 27, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop preclinical mouse models expressing HIV proteins that replicate metabolic comorbidities observed in persons living with HIV, including obesity, cardiovascular disease, chronic kidney disease, osteoporosis, cancers, frailty, and cognitive decline. The research...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of California, Davis $180,109 on June 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate restoration of microbiota signaling pathways using non-biotic substitutes—termed "faux-biotics"—to control opportunistic infections during chemotherapy-induced dysbiosis. The project addresses the loss of colonization resistance that occurs...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded the University of Illinois $882,709 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate adipose tissue dysfunction in simian immunodeficiency virus (SIV)-infected rhesus macaques treated with combination antiretroviral therapy (cART). The research addresses lipodystrophy and metabolic complications that affect over 75% of chronic HIV...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Northwestern University $794,032 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate mechanisms of intestinal barrier dysfunction in people living with HIV on antiretroviral therapy and to evaluate restoration of the glycan A1,2-fucose as a therapeutic intervention. The research addresses persistent gut leakiness and microbial translocation in HIV-positive individuals despite treatment, conditions that drive chronic inflammation and premature aging. The project examines how depletion of A1,2-fucose—a prebiotic glycan produced by intestinal epithelial cells—contributes to reduced epithelial resilience and loss of short-chain fatty acid-producing bacteria. The work tests two mechanistic pathways: a microbiome-independent arm in which A1,2-fucosylated glycoconjugates stabilize tight junctions, and a microbiome-dependent arm in which the glycan fuels fucose-utilizing commensals to boost short-chain fatty acid production. Preliminary data show that A1,2-fucose supplementation restores short-chain fatty acid production in ex vivo anaerobic stool fermentations from people living with HIV, suggesting it is a modifiable control point for microbiome composition and epithelial resilience. Work is performed in Chicago, Illinois. The period of performance runs through May 31, 2031. The award is structured as a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $794.0k | 9/2/26 |