Project Grant R21DK144827
- This Project Grant award of $200,000.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to investigate the role of oxidative stress and the transcription factor Nrf2 in modulating the phenotype of vascular smooth muscle cells (VSMCs) and improving arteriovenous fistula (AVF) maturation. The research, to be conducted at the University of North...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $132,270 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Florida. The grant aims to develop a multi-functional 3D-printed biomaterial scaffold that improves the vascularization, engraftment, and immunoprotection of transplanted pancreatic islets for the treatment of type 1 diabetes. The project has two key objectives: 1) Identify...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $305,368 Project Grant to Maguro Surgical Inc. to develop a novel magnetic system for the endoscopic retrieval of kidney stone fragments. The goal of this project is to create a more effective method for removing residual kidney stone fragments following minimally invasive procedures, which can reduce...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is focused on investigating the role of vascular fibroblasts in postoperative venous stenosis. The $2,777,206 award to the University of Miami aims to demonstrate the central role of venous fibroblasts in the stenotic remodeling of arteriovenous fistulas (AVFs) created for dialysis in...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is focused on developing novel bioengineered regenerative medicine solutions based on vasculogenic regenerative medicine technology. The $543,826 award, granted on December 10, 2024, aims to investigate the mechanisms underlying in vivo vasculogenic reprogramming, specifically examining...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a component of the National Institutes of Health, awarded a $350,000 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Microvascular Tissues, Inc. The grant supports the evaluation of a microvascular tissue graft treatment in rat models of diabetic peripheral neuropathy. The project aims to assess the ability of this novel microvascular tissue graft to improve...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through its Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $350,000 Project Grant to Katharos, Inc. on Jun 20, 2025. The grant supports the development of a novel extracorporeal technology, the "Phosfilter" device, which aims to enhance phosphate removal from the blood of hemodialysis patients and reduce the incidence of high phosphate-associated morbidity and...
- This federal Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $306,867 award to Dupage Medical Technology Inc. supports the development of a new drug to treat ischemia-reperfusion injury associated with kidney transplantation. The project aims to develop a therapy that can reduce inflammation and thrombosis without causing excessive...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $314,355 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Angiotensin Therapeutics Inc., a biotechnology company located in Evanston, Illinois. The funding supports research to develop a soluble form of the enzyme Angiotensin Converting Enzyme 2 (ACE2) as a potential treatment for delayed graft function (DGF), a form of acute kidney injury that...
- This federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is focused on developing a new class of biodegradable and elastic vascular grafts for hemodialysis. The $298,371 award to Anova Biomedical, Inc. aims to address the limitations of current expanded polytetrafluoroethylene (ePTFE) arteriovenous grafts, which have high failure rates...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $437,010 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of North Carolina at Chapel Hill. The grant, titled "Leveraging 'Smart Stent' Platform Technologies for AVF Maturation and More", aims to develop and test a biodegradable magnesium "smart stent" technology to improve early blood flow and minimize stenosis in arteriovenous fistulas (AVFs), which are the primary vascular access for hemodialysis patients. Key objectives include optimizing the scaffold strength and degradation profiles of the smart stent, evaluating its technical feasibility and safety in a pig model, and documenting its clinical efficacy compared to standard treatments. The project period runs from September 2025 to August 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $437.0k | 9/8/25 |