Project Grant R21DK139534
Award Date 9/1/25
Completion Date 8/31/28
Dollars Obligated $573K
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
- This federal Project Grant award, in the amount of $416,005, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The purpose of the award is to define the molecular mechanisms of human astrovirus (HAstV) entry into human cells, with the goal of identifying targets for the development of vaccines and therapies. The research aims to use structural, biophysical, and virological...
- This $146,922 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The University of Pittsburgh is conducting research to investigate the role of gut protist-derived compounds on dietary antigen presenting dendritic cells in celiac disease. The project aims to understand how certain gut microbes can protect against virus-mediated loss of oral...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $226,641 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Colorado-Denver. The grant, awarded on December 5, 2024 with a completion date of November 30, 2026, will support research to examine how the intestinal microbiome and the pattern recognition receptor NOD2 expressed in intestinal epithelial cells impact pathogenesis of Coxsackievirus B3, an enteric virus...
- This $107,010 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program supports research into the impact of diet-induced obesity on immune responses to enteric viral infections, specifically norovirus. The principal investigator's preliminary data indicates that mice fed a high-fat diet prior to norovirus infection clear the infection faster than control mice, suggesting obesity may enhance...
- This $2,920,356 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand the role of norovirus capsid dynamics in enabling immune evasion. The project aims to leverage the highly tractable mouse norovirus system to elucidate the structural changes and host metabolite interactions that allow the virus to switch between antibody-recognized and...
- This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), is focused on investigating how hypoxia (low oxygen) impacts the antiviral functions of human intestinal epithelial cells in relation to enteric viral infections. The $659,313 award, effective April 4, 2025 through March 31, 2030, will fund research utilizing human intestinal organoids and gut-on-a-chip technologies to...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $779,235 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to the University of California, Santa Cruz to study the mechanisms and consequences of cyclic di-GMP control of motility and biofilm formation in Vibrio cholerae. The research aims to address major gaps in understanding the interplay between V. cholerae's flagellum, pili, and cyclic di-GMP signaling in the...
- This Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $431,004 to the University of California, Davis to investigate the dynamic interplay between human cells and the pathogenic amoeba Entamoeba histolytica during the process of "trogocytosis" or cell-nibbling. The research aims to further understand the mechanisms by which E. histolytica attacks and kills human cells, with the goal of...
- This Project Grant award of $696,544 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand the contractile attachment mechanisms of the ventral disc in the Giardia lamblia parasite. The research team at the University of California, Davis will leverage new CRISPR-based genetic tools and live imaging approaches to evaluate how key structural elements of the ventral disc...
- The University of California, San Diego (UCSD) was awarded a $3,194,992.00 Project Grant by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant, awarded on July 16, 2025, supports research to study the roles and regulation of tissue-resident CD8 T cells during a persistent viral infection. The research aims to investigate the mechanisms that allow immune cells to adapt and maintain a long-term...