This Project Grant award of $829,985.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research supports research to develop new Drosophila, mouse, and human podocyte models to study the interactions between HIV and APOL1-G1 risk alleles that contribute to the development of HIV-associated chronic kidney diseases (HIV-CKD). The research aims to define the mechanisms by which APOL1-G1...
This $223,176 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research on the impact of APOL1 copy number variations (CNVs) on kidney disease susceptibility in African Americans. The award recipient, Beth Israel Deaconess Medical Center (BIDMC), will develop computational approaches to characterize the risk variant architecture of APOL1 CNVs and determine the...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $133,500 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to Boston Medical Center Corporation (BMC) with a start date of September 1, 2024 and end date of August 31, 2026. The grant will fund research on the relationship between APOL1 genotypes and biomarkers of immune activation and tubular injury in the context of chronic kidney disease (CKD) in sub-Saharan...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $521,237 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Albert Einstein College of Medicine. The grant, titled "Community Health Workers in an Interdisciplinary Outpatient CKD Clinic to Optimize Social Care Navigation, Patient Engagement, and Home Dialysis Utilization- The CHOOSE HOME Trial", will support a pilot randomized trial to...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $200,000.00 to New York University School of Medicine to conduct a case-cohort study investigating novel determinants of risk for living kidney donors. The key objectives are to: 1) use qualitative research to inform recruitment strategies and messaging to maximize participation of...
This $820,119 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research focused on elucidating the mechanobiological functions of novel cytoskeletal structures in podocytes to reveal new therapeutic opportunities for kidney glomerular diseases. The primary research aims to better understand the mechanisms underlying podocyte homeostasis,...
This $400,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to understand the earliest events in podocyte injury in collagen IV nephropathies. The goal is to investigate how processing of mutant collagen IV proteins injures podocytes at early stages, leading to chronic kidney disease and renal failure. The research uses...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to investigate the genetic basis of nephrotic syndrome and its impact on kidney function and disease. The $265,188 award aims to discover the association of genetic variations in the NPHS1 gene, which encodes the nephrin protein, with kidney traits and diseases in a large...
This $194,380 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to study the role of the protein LIM-nebulette in helping podocytes (kidney cells) adapt to mechanical stress, such as that caused by severe hypertension. The grantee, Icahn School of Medicine at Mount Sinai, will use a novel mechanical stretch platform and high-content image analysis to understand how...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $2,202,378 to the Icahn School of Medicine at Mount Sinai to conduct research on the protective role of the KLF2 gene in diabetic kidney disease (DKD). The key goals are to determine how KLF2 is regulated in diabetic conditions, how it protects against glomerular endothelial...