Project Grant R21DK138409

Award Date 9/22/23
Completion Date 8/31/25
Dollars Obligated $337K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
New York, USA
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This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $155,562 to investigate the effects of activating branched-chain amino acid (BCAA) catabolism on acute kidney injury (AKI) and the progression to kidney fibrosis. The award recipient, The Research Foundation for the State University of New York, doing business as Stony Brook University, will use advanced...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $434,950 to The Research Foundation For The State University Of New York to develop a microfluidic device that models the complex structure and selective filtration function of the kidney's glomerulus and Bowman's capsule. This "Glomerular-Bowman's Capsule System on a Chip" will...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $436,277 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Delaware. The grant titled "NEPHROGENESIS ON A CHIP: AN SIMPLE MODULAR PLATFORM TO SPATIALLY PATTERN EXTRACELLULAR MATRIX, STROMAL CELLS, AND SOLUBLE FACTORS" aims to develop an easy-to-use 3D in vitro model of the developing nephron that allows spatial patterning...
This $194,380 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to study the role of the protein LIM-nebulette in helping podocytes (kidney cells) adapt to mechanical stress, such as that caused by severe hypertension. The grantee, Icahn School of Medicine at Mount Sinai, will use a novel mechanical stretch platform and high-content image analysis to understand how...
This $820,119 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research focused on elucidating the mechanobiological functions of novel cytoskeletal structures in podocytes to reveal new therapeutic opportunities for kidney glomerular diseases. The primary research aims to better understand the mechanisms underlying podocyte homeostasis,...
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This $1,470,094 project grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) will fund research by New York University School of Medicine to optimize pre-implantation kidney transplant biopsy interpretation using artificial intelligence (AI) assistance. The key products and services to be delivered under this 5-year project include: Developing a comprehensive unbiased atlas of histopathology in pre-implantation deceased donor kidney biopsies using...
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The Research Foundation For The State University Of New York, doing business as Stony Brook University, received a $337,284 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to develop a single-cell spatial multiplex in situ tagging (MIST) technology and apply it to kidney biopsy samples for functional proteome studies. This novel technology will enable the measurement of hundreds of functional proteins, including biomarkers, signaling proteins, and transcription factors, in kidney tissue at single-cell resolution. The completion of this 2-year project will generate an enabling technology accessible to the broader kidney research community to investigate kidney disease mechanisms and identify potential therapeutic targets from a clinically relevant perspective. Stony Brook University will serve as the prime awardee on this project grant, which begins on September 22, 2023 and runs through August 31, 2025.

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