This $561,893 Project Grant was awarded on September 19, 2024 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to systematically evaluate the molecular cascade involving Type 2 Diabetes (T2D) effector genes, the regulatory factors RFX3 and RFX6, and T2D-associated genetic variants in human islet cell generation, survival, and function. The research will...
This federal Project Grant award of $526,902, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop novel statistical methods, computational algorithms, and user-friendly software to study individual health trajectories relevant to disease onset and progression for biobank-scale real-world data. The research project, titled "Transforming...
This $530,890 Project Grant award was issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The project aims to identify tissue- and disease-specific processes that underlie type 1 diabetes (T1D) susceptibility by comparing autoimmune T cell development and function in mouse models expressing T1D-associated major histocompatibility complex class II (MHC-II) alleles...
This $644,524 federal Project Grant award, funded by the National Science Foundation (NSF) Integrative Activities program (CFDA 47.083), supports a collaborative research project between Howard University and North Carolina A&T State University to identify the dynamic structure of type 2 diabetes (T2D) progression and develop personalized treatment approaches. The key products and services to be delivered under this five-year award include: Constructing a theoretical threshold model to...
This $689,177 Project Grant award under the National Institute of Diabetes and Digestive and Kidney Diseases' (NIDDK) Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports comprehensive research to uncover the relationships between environmental, genetic, and 'omic factors influencing type 2 diabetes (T2D) risk. The key objectives are to: 1) Develop software and data to identify longitudinal exposome and polygenic predictors of T2D and glycemic traits across...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $376,208 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Georgia Research Foundation, Inc. The goal of this 1.5-year project is to develop and pilot test a culturally adapted digital health application for older Hispanic adults with type 2 diabetes. The app will aim to improve health literacy, medication adherence, and overall...
This $199,999 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports the development of innovative artificial intelligence (AI)-based methods to discover potent, orally available small-molecule heparanase inhibitors. Heparanase is an enzyme that plays a key role in the development of diabetic nephropathy, a complication of diabetes...
This $338,007 federal Project Grant was awarded on July 1, 2024 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund research at the University of California, Irvine to investigate how dietary factors can impact the epigenetic silencing of transposable elements (TEs) and influence organismal health. The research aims to leverage natural TE variation and...
This $772,848 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop and evaluate an innovative, adaptive mobile phone-delivered intervention to support adults with Type 2 diabetes. The intervention will be tailored based on an existing typology of diabetes-specific family functioning and will include components such as goal...
This federal Project Grant award of $800,000.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund research conducted by the Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, Massachusetts to develop a novel computational pharmacology approach for coordinating the activity of multiple neuron types in the brain to regulate energy...