This Project Grant award of $1,610,888.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to define the mechanisms by which CD4+ T cells drive autoimmunity in type 1 diabetes (T1D). The research aims to characterize the cross-reactivity between microbial and self-antigens recognized by T cells in T1D patients, and to identify biomarkers in peripheral...
This $107,948 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research by Case Western Reserve University investigating the role of microRNA-146a (miR-146a) in regulating autoimmunity in type 1 diabetes. The research aims to (1) elucidate how miR-146a deficiency affects T cell autoreactivity and T regulatory cell function in a mouse...
This Cooperative Agreement award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,207,770.00 to The Trustees of Columbia University in the City of New York to support research aimed at understanding the thymic epithelial and hematopoietic stem cell-intrinsic immune abnormalities that drive type 1 diabetes (T1D). The project will utilize optimized human...
This Cooperative Agreement award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $1,208,620.00 to the University of Massachusetts Medical School (UMMS) over the period of January 1, 2025 to December 31, 2026. The funding will support the development and utilization of novel humanized mouse models to study the dynamic interactions between human immune...
This federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $602,531 to study the potential of lymph node fibroblastic reticular cells in promoting peripheral tolerance and reducing autoimmunity in type 1 diabetes. The primary awardee is The Trustees of Columbia University in the City of New York, with sub-awards to the University...
This federal Project Grant award, valued at $575,394.00 and funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports a multi-ancestry genetic analysis of Type 1 Diabetes (T1D) and related conditions. The project aims to develop a multi-ancestry T1D polygenic risk score to better predict risk across diverse populations, as well as to identify genetic subtypes of T1D...
This is a federal Cooperative Agreement awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $1,232,846 award to the Scripps Research Institute in La Jolla, CA will fund research to build a vascularized micro-organ platform to study the mechanisms of immune attack and beta cell death in type 1 diabetes. The key objectives are to develop induced pluripotent stem...
This Cooperative Agreement award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is funding a research project led by Yale University to develop advanced pancreatic-immune organoid models of Type 1 Diabetes (T1D) subtypes and therapeutic responses. The $1,201,988 award, which commenced on January 1, 2025 and is set to be completed by December 31, 2026, aims to...
This federal Project Grant award, with ID R01DK142414, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $561,893 award aims to systematically evaluate the molecular cascade involving Type 2 Diabetes (T2D) effector genes, the transcription factors RFX3 and RFX6, and T2D-associated genetic variants in human islet cell generation, survival, and function under...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $352,618 to the Trustees of the Colorado School of Mines for a 5-year period from July 1, 2024 to June 30, 2029. The research aims to determine if cytokine-stressed beta cells contribute to the degradation of the peri-islet extracellular matrix (ECM) in the early stages of type 1...