Project Grant R01DK137993

Award Date 7/22/24
Completion Date 6/30/29
Dollars Obligated $689K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
ROXBURY CROSSING, MA 02120, USA
Similar Awards
This $561,893 Project Grant was awarded on September 19, 2024 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to systematically evaluate the molecular cascade involving Type 2 Diabetes (T2D) effector genes, the regulatory factors RFX3 and RFX6, and T2D-associated genetic variants in human islet cell generation, survival, and function. The research will...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $823,473 Cooperative Agreement under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The 5-year project aims to integrate clinical and multi-omic data to refine definitions of prediabetes and type 2 diabetes, identify subtypes associated with complications, and develop...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), a 5-year, $575,394 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The goal of this research project is to develop a multi-ancestry polygenic risk score for predicting type 1 diabetes (T1D) and related autoimmune conditions. Leveraging a diverse dataset, the...
This $784,636 Cooperative Agreement award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports the "Generation and Assessment of Multi-Omic Informed Subtypes of Type 2 Diabetes in Diverse Populations (GEMS-T2D)" project. The project aims to: 1) Use machine learning to integrate clinical, genetic, and metabolomic data and define new Type 2 diabetes subtypes; 2) Evaluate the...
The federal Project Grant award R01DK139632, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the genetic and metabolomic underpinnings of type 2 diabetes (T2D) and prediabetes phenotypes in the South Asian population. With a total funding of $583,732.00 over the award period from January 2025 to December 2029, the project will leverage the...
This federal Cooperative Agreement award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under CFDA program 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research, provides $1,286,116.00 to Wake Forest University Health Sciences to expand the physiological understanding of Type 2 Diabetes (T2D) subtypes across diverse, multiethnic populations. The research aims to assemble integrated clinical, genetic, metabolomic, and social determinants of health...
This $698,646 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research aims to define the functional and disease relevance of putative beta-cell subtypes in type 2 diabetes. The key objectives are to: 1) use novel single-cell epigenomic tools to determine if functionally- and epigenetically-defined beta-cell subsets are the same; 2) use conditional deletion mouse models...
This $530,890 Project Grant award was issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The project aims to identify tissue- and disease-specific processes that underlie type 1 diabetes (T1D) susceptibility by comparing autoimmune T cell development and function in mouse models expressing T1D-associated major histocompatibility complex class II (MHC-II) alleles...
This $4,087,560 five-year Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research aims to develop a comprehensive database of functionally important RNA modifications in key metabolic tissues related to type 2 diabetes and obesity. The prime awardee, Joslin Diabetes Center, will work with sub-awardees at the University of Pennsylvania, University of Chicago, and University...
This $248,915 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the role of epigenetics and cytokines in type 2 diabetes among African-ancestry populations. The research, led by the University of Maryland, Baltimore, will leverage data from two existing cohorts - the AADM study in sub-Saharan Africa and the RODAM study in Africa...

This $689,177 Project Grant award under the National Institute of Diabetes and Digestive and Kidney Diseases' (NIDDK) Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports comprehensive research to uncover the relationships between environmental, genetic, and 'omic factors influencing type 2 diabetes (T2D) risk. The key objectives are to: 1) Develop software and data to identify longitudinal exposome and polygenic predictors of T2D and glycemic traits across multiple diverse biobanks, and 2) Catalog circulating biomarkers associated with the exposome and genome and relate them to incident diabetes. The Broad Institute, Inc. is a sub-grantee providing data integration, polygenic risk score, and Mendelian randomization analysis services to support the research. This grant leverages established federal resources and aims to advance systems genetics/physiology approaches to discover novel exposome and gene-environment interactions underlying T2D.

Generated 5/13/25, 4:28 AM