Project Grant R21DE036073
- This federal Project Grant award in the amount of $469,830.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant aims to identify oral bacterial species with anti-cancer properties and evaluate their potential for preventing or treating oral squamous cell carcinoma (OSCC). Specifically, the study will assess the effects of Streptococcus mitis and Haemophilus parainfluenzae on OSCC...
- This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $434,170 to the University of Texas Health Science Center at Houston (UTHealth) to develop engineered bacterial in situ vaccines against oral cancer. The key products and services to be delivered under this grant include: 1) developing non-pathogenic E. coli bacteria that can be programmed to secrete the...
- The National Institute of Dental and Craniofacial Research awarded the University of Florida $351,833 on August 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the functions and molecular mechanisms of protein O-phosphorylation in Streptococcus mutans, the primary bacterial agent of dental caries. The project addresses a gap in understanding how O-phosphorylation—a post-translational protein modification—regulates S. mutans adaptation and virulence in...
- The National Institute of Dental and Craniofacial Research awarded the University of Georgia Research Foundation $644,452 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop engineered synthetic low-density lipoprotein nanoparticles encapsulated with 7-dehydrocholesterol (7DHC-LDLs) as an adjuvant nanotechnology to enhance anti-tumor immunity in head and neck squamous cell carcinoma when used in combination with immune checkpoint inhibitors. The...
- The National Institute of Dental and Craniofacial Research awarded the University of California, Los Angeles $410,706 on July 16, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct genome-wide analysis of Fusobacterium nucleatum virulence mechanisms and their role in oral and systemic disease. The funded research identifies F. nucleatum virulence factors across the bacterial genome and characterizes the function of TetR-regulated ABC transporters in oxidative...
- The National Institute of Dental and Craniofacial Research awarded the University of Florida $623,879 on July 9, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate ecological approaches for caries prevention and management through prebiotic and probiotic mechanisms. The research examines how the prebiotic candidate N-acetylglucosamine modulates oral microbial diversity and biofilm metabolism to enhance anti-caries pathways expressed by health-associated...
- The National Institute of Dental and Craniofacial Research awarded Rutgers The State University of New Jersey $431,750 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to design a novel periodontal vaccine using in silico methodology. The recipient, operating as RBHS-School of Nursing from Newark, New Jersey, will employ subtractive proteomics, structural bioinformatics, reverse vaccinology, and immunoinformatics tools to develop a multivalent,...
- The National Institute of Dental and Craniofacial Research awarded the University of Florida $574,966 on June 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate functional amyloid formation in Streptococcus mutans, the bacterium that causes dental caries. The research characterizes amyloid-forming proteins in S. mutans—including P1 (AGI/II), WAPA, CNM, and SMU_63—and examines how naturally occurring adhesin truncation products regulate biofilm...
- The National Institute of Dental and Craniofacial Research awarded the University of Southern California $481,739 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop three-dimensional organoid models representing the stepwise neoplastic evolution of head and neck squamous cell carcinoma. The recipient institution will create organoids directly from normal human oral tissues, patient-derived leukoplakia samples, and head and neck squamous cell...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded The Washington University $427,625 on February 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds research to develop and evaluate radiation-guided theranostic agents for detecting and monitoring response to oral cancer treatment. The research leverages radiation-inducible antigens, specifically...
The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded the University of Florida $458,877 on August 1, 2026, through the Oral Diseases and Disorders Research program (CFDA 93.121) to develop an oral vaccine targeting Fusobacterium nucleatum in oral squamous cell carcinoma. The recipient will generate a recombinant Lactobacillus gasseri expressing B-cell linear epitopes of two F. nucleatum surface proteins—FAP2 and FADA—designed to prevent bacterial colonization and reduce oral cancer severity. The vaccine targets the bacterium's interaction with epithelial cells bearing the tumor-associated GAL-GalNAc carbohydrate moiety, which triggers carcinogenesis through increased Wnt signaling. The research will assess vaccine efficacy using both preventive and therapeutic murine models of oral squamous cell carcinoma. The work is performed at the University of Florida, Gainesville, Florida, with a period of performance from August 1, 2026, through July 31, 2028. This is a Project Grant (R21 mechanism), which supports exploratory and developmental research in basic, translational, and clinical areas within the institute's mission to advance dental, oral, and craniofacial health knowledge and translate findings into prevention and treatment strategies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $458.9k | 7/27/26 |