Project Grant R21DE035695
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded $315,000 to the University of California, Los Angeles on July 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate bone morphogenetic protein (BMP)-dependent mechanisms underlying mandibular outgrowth and to resolve molecular pathways disrupted in micrognathia, a congenital anomaly affecting mandibular...
- The National Institute of Dental and Craniofacial Research awarded the University of Massachusetts Lowell $100,676 on September 30, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop a three-dimensional in vitro human periodontal sulcus tissue model capable of reproducing healthy and disease states of gingivitis and periodontitis. The recipient will engineer a sustained tissue culture system that mimics key anatomical features of the gingival sulcus—including...
- The National Institute of Dental and Craniofacial Research awarded the University of California, Los Angeles $449,886 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research on the regulation of early mandibular morphogenesis by the homeobox protein MSX1. The research addresses craniofacial anomalies, which are among the most common congenital conditions. Mutations in the MSX1 gene are associated with tooth agenesis, cleft palate, and...
- The National Institute of Dental and Craniofacial Research awarded The Regents of the University of California, San Francisco $696,710 on August 10, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the role of the genome organizer protein SATB1 in salivary gland maturation and regeneration. The research addresses the absence of viable long-term treatments for salivary gland dysfunction resulting from disease or chronic injury, particularly xerostomia...
- The National Institute of Dental and Craniofacial Research awarded the University of New Mexico $305,000 under the Oral Diseases and Disorders Research program (CFDA 93.121) on June 5, 2026. The award funds research into the mechanisms by which PRDM3 and PRDM16 chromatin modifiers control craniofacial cartilage development. The research uses genetic mouse models, in vitro cell culture systems, and molecular tools to test whether precise levels of these paralogs fine-tune Wnt/β-catenin...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded $151,590 to The Johns Hopkins University on February 18, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research determining the role of RAFTLIN-2 in neural crest cell specification and migration. The research investigates how RAFTLIN-2, a gene upregulated during cranial neural crest cell specification,...
- The National Institute of Dental and Craniofacial Research awarded the Stowers Institute for Medical Research $124,200 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate ribosome biogenesis regulation of neural crest cell differentiation in development and disease. The funded research examines how ribosomal RNA transcription and ribosome biogenesis control neural crest cell fate acquisition and differentiation during craniofacial...
- The National Institute of Dental and Craniofacial Research awarded the Stowers Institute For Medical Research $371,250 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the pathogenesis, phenotypic variation, and prevention of craniofacial anomalies. The project examines how genetic and environmental factors interact to produce craniofacial birth defects—conditions such as cleft lip and palate, micrognathia, and craniosynostosis that account...
- The National Institute of Dental and Craniofacial Research awarded The University of Kentucky Research Foundation $154,000 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to elucidate the etiology of Schneckenbecken dysplasia, a rare congenital skeletal disease caused by mutations in the SLC35D1 nucleotide-sugar transporter gene. The recipient will generate CRISPR models of patient-specific SLC35D1 variants using Xenopus tropicalis to understand how loss of...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded $128,191 to the University of California Irvine on May 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award supports a project grant (K99DE034828) to identify non-coding genetic sources of mammalian craniofacial variation and test their functional impact on facial morphogenesis. The research addresses the...
The National Institute of Dental and Craniofacial Research awarded University of Massachusetts Lowell $445,389 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate SATB2 as a mandible-specific mediator of GLI3 transcription in craniofacial development. The research examines how specific transcription factor co-factors regulate GLI3 activity in the developing mandible without requiring a sonic hedgehog morphogen gradient, contrasting with established models in limb and neural tube development. The work focuses on the physical and functional interactions between SATB2 and GLI3 in cranial neural crest cells of the developing mandible, with the goal of establishing a new paradigm for modeling tissue development and disease. The research investigates how GLI3 and co-factors such as HAND2 and SATB2 utilize low-affinity divergent GLI binding motifs and interact with additional transcription factors to execute distinct gene regulatory networks. Performance occurs in Lowell, Massachusetts, with a period of performance from August 1, 2026, through July 31, 2028. University of Massachusetts Lowell's Office of Sponsored Programs serves as the recipient, administering the award through its Office of Research Administration-Lowell division. The assistance type is a Project Grant, a form of support under NIDCR's extramural research program for basic and translational research in dental, oral, and craniofacial health and disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $445.4k | 8/3/26 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
LK1485FFATAREPORTED91025S | Childrens Hospital Medical Center | Project Grant R21DE035695 | $222.8k | 9/10/26 |