Brigham & Women's Hospital Inc. was awarded a $653,547 Project Grant from the National Institute on Deafness and Other Communication Disorders (CFDA 93.173 - Research Related to Deafness and Communication Disorders) to investigate the immune dysregulation mechanisms underlying persistent post-COVID-19 olfactory dysfunction. The grant aims to elucidate the specific pathways leading to prolonged disruption of chemosensory function, including the role of infiltrating immune cells and inflammatory mediators in impairing olfactory stem cell development and sensory neuron survival. As a sub-recipient, Harvard T.H. Chan School of Public Health will provide statistical expertise and computational analysis of single-cell RNA sequencing data to characterize the heterogeneity of nasal epithelial and immune cell populations in patients with post-COVID anosmia and dysgeusia. The overarching goal is to identify novel potential therapeutic targets for treating persistent COVID-19-related smell and taste disturbances.
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