This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), will support a $907,500 research study on the relationship between exposure to the drug xylazine and the risk of skin and soft tissue infections (SSTI) among people who inject drugs (PWID). The study will prospectively recruit 200 PWID in Lowell, Massachusetts and follow them for 3 months. It will quantify xylazine exposure using laboratory...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $789,677 to the Research Triangle Institute (RTI International) to conduct a community-based, longitudinal, mixed-methods study investigating the growing crisis of xylazine exposure among people who use drugs (PWUD) in the Southeastern U.S. The key products and services to be delivered through this funding include: 1) employing...
This $238,500 federal Project Grant award was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award supports research to investigate the effects of the veterinary sedative xylazine, which has become prevalent in illicit opioid supplies, on inhibitory transmission in the prefrontal cortex. Specifically, the research aims to determine if xylazine and opioids exert synergistic effects on prefrontal cortex inhibitory...
This $146,922 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support a mixed methods study to develop a natural language processing (NLP) algorithm to identify patients exposed to fentanyl adulterated with the veterinary sedative xylazine (FAAX). The research aims to advance understanding of FAAX-related overdose, skin wounds, withdrawal experiences, and treatment practices. The study will involve...
This $392,940 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the interactions between opioids and the veterinary drug xylazine. The research aims to improve understanding of why use of opioid/xylazine mixtures has rapidly increased, and to elucidate factors contributing to this trend, in order to drive the discovery of safe and effective treatments. The project, awarded...
This Project Grant award for $423,708 was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The funding will support research to investigate the effects of fentanyl-xylazine drug mixtures on cardiorespiratory function and subjective effects in rats. Specifically, the research aims to characterize how xylazine impacts fentanyl-induced changes in heart rate, blood pressure, temperature, and respiration, as well as determine if...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will provide $233,250 to The Washington University in St. Louis to conduct research on the prevalence of the drug xylazine in the illicit drug supply and the etiology of xylazine-related invasive infections. The key objectives are to: 1) conduct active surveillance of the local illicit drug supply in St. Louis, Missouri using mass spectrometry and...
This $387,750 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research by Mercer University to investigate the molecular pharmacology of the drug xylazine and its effects on adrenoceptors. The research aims to assess xylazine's binding affinity and functional profiles at different adrenoceptor subtypes expressed in vascular smooth muscle cells, as well as directly test the hypothesis that...
The U.S. National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded a $688,271 Project Grant to Yale University to conduct a study examining spatial and temporal variability in a state's illicit drug market. The key objectives of this 5-year project are to: (1) expand street-based testing of drug samples from representative samples of people who use drugs, (2) develop a robust wastewater sampling and testing system to determine...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $212,200 to the Research Triangle Institute (RTI International) to conduct a 24-month mixed-methods study examining the feasibility and acceptability of a community-based drug checking (CBDC) program operating through a syringe service program (SSP) in rural and tribal communities in Minnesota. The goal is to use the CBDC program to collect...