This federal Project Grant award of $695,250, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research at Howard University examining the role of endothelial injury and myeloid cell migration in the activation of inflammasomes in HIV infection and cocaine exposure. The research aims to characterize myeloid cell populations in the brains of HIV-transgenic mice under chronic cocaine treatment, evaluating the number,...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $240,108 to Drexel University to elucidate the corticolimbic circuit and neuroimmune mechanisms underlying the dysregulation of reward-seeking behavior in the comorbid condition of HIV and cocaine use disorder (CUD). The research aims to use circuit-specific optogenetics and chemogenetics in mouse models to understand how HIV infection,...
This Project Grant award of $558,668 from the National Institute on Drug Abuse (NIDA) under CFDA Program 93.279 - Drug Use and Addiction Research Programs supports research to elucidate the shared and distinct molecular mechanisms underlying the interplay between HIV, substance use disorders (SUD), and neuropsychiatric/neurodegenerative conditions. The award to Massachusetts Institute of Technology (MIT) aims to leverage single-cell transcriptomic, epigenomic, and spatial datasets along with...
The National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded a $1,372,480 Project Grant to the Board of Regents of the University of Nebraska's University of Nebraska Medical Center (UNMC). The grant supports a 5-year research study focused on elucidating the molecular mechanisms underlying the interplay between HIV transactivator of transcription (Tat) protein, cocaine, and combination antiretroviral therapy (cART) in activating the...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $454,470.00 in funding to Drexel University to develop a new imaging pipeline and analytical approach for examining the spatial architecture of histone dopaminylation in the central nervous system (CNS) of mice with HIV infection that self-administer cocaine. The goal is to connect molecular-level epigenetic changes with behavioral outcomes...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $2,223,769 to the University of California, San Diego (UCSD) to conduct research on the intertwined mechanisms of HIV and opioid use on mitochondrial-mediated inflammasome activation and neurotoxicity. The research aims to elucidate how the convergence of HIV infection and opioid use leads to more severe neurological consequences, including...
The National Institute on Drug Abuse (NIDA) awarded a $687,416 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco, CA. The grant supports research to develop therapeutically effective latency-promoting agents (LPAs) that can "block" HIV reactivation and "lock" HIV in a silenced state, even in the presence of addictive substances, for people living...
This federal Project Grant award, totaling $2,812,966.00, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award supports research investigating the impacts of drug abuse-mediated inflammatory perturbations on the affinity maturation of anti-CD4 autoantibodies and poor immune reconstitution from antiretroviral therapy (ART) in individuals with HIV. Specifically, the research aims to determine the mechanisms of...
This Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) provides $563,742 in funding to Old Dominion University (ODU) and its affiliated research foundation (Odurf) to conduct research on the role of dysregulated lipid metabolism in microglial activation and neurological symptoms associated with HIV and cocaine use. The key objectives are to determine the mechanisms by which HIV proteins and cocaine impact microglial lipid...
This Project Grant award of $2,312,085, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to investigate the molecular mechanisms linking HIV infection and opioid use disorder that contribute to neuroinflammation and HIV-associated neurocognitive disorders (HAND). The research, led by the Trustees of Boston University's Medical Campus, will utilize primary human iPSC-derived microglia cultures to...