This $376,078 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research on the relationship between cannabis use for coping purposes and cannabis use quantity and frequency. The key objectives are to: 1) Experimentally test if cannabis use increases after stress induction among individuals who use cannabis for coping, 2) Examine if social anxiety and inhibitory control moderate the...
This $1,790,186 Project Grant awarded by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to investigate the mechanisms governing stress-immune interactions in people living with HIV (PLWH) and their associated distress and cannabis use disorder (CUD). The research project will use a cross-diagnostic approach to: Determine the hypothalamic-pituitary-adrenal (HPA) and immune response to acute stress among healthy controls, PLWH,...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $242,310 to The Medical College of Wisconsin, Inc. to conduct research on the mechanisms by which the stress hormone corticosterone (CORT) regulates the endocannabinoid signaling system in the prefrontal cortex. The goal is to enhance understanding of how CORT-induced mobilization of the endocannabinoid 2-arachidonoylglycerol (2-AG) may...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $360,100 to support research on the socio-structural determinants of cannabis and derived psychoactive cannabis product use and consequences among young adults. The research will be conducted by George Washington University, a private research university with extensive experience managing federal grants and contracts across scientific,...
The U.S. National Institute on Drug Abuse (NIDA), through the Drug Use and Addiction Research Programs (CFDA 93.279), awarded a $163,568 Project Grant to Brown University to conduct a multimodal study on the relationship between cannabis use, trauma, and self-regulatory cognitive processes. The study aims to examine how decision-making processes, such as reward motivation and inhibitory control, relate to cannabis use among young adults following a potentially traumatic event. The project will...
This federal Project Grant award, totaling $3,967,443.00, was granted by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant will fund two full-factorial laboratory studies to determine the impact of acute delta-9-tetrahydrocannabinol (THC) administration on the motivational, subjective, and physiological effects of combustible cigarettes and electronic cigarettes. The studies will use standardized NIDA products and evaluate...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $205,360 to The Medical University of South Carolina to develop and test a novel in-person brief intervention addressing frequent cannabis use in emerging adults. The project aims to enhance the career development of the Principal Investigator, Dr. Gex, in patient-oriented research focused on the prevention and early intervention of substance use...
This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to examine the potential effectiveness of transcranial direct current stimulation (tDCS) paired with reappraisal training for the treatment of cannabis use disorder (CUD). The $247,875 award will fund a study to investigate if pairing tDCS of the dorsolateral prefrontal cortex with reappraisal training can enhance emotional regulation,...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will provide $568,855 to The Medical University of South Carolina (MUSC) from May 1, 2024 to April 30, 2026. The project aims to identify the neurobiological mechanisms underlying changes in PTSD-like symptoms after cannabis use. The research will characterize cell-specific neuroadaptations in the nucleus accumbens core and ventral pallidum in response to...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund a $233,250 study examining the relationship between early cannabis use (ECAN) and opioid use disorder (OUD). The key objectives are to: Assess the association between ECAN and both proximal (e.g., initial opioid responses) and distal (e.g., OUD severity) aspects of opioid involvement, including whether these associations are modified by...
This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), will support an experimental evaluation of the mechanisms through which acute stress increases motivation to use cannabis in individuals with cannabis use disorder (CUD). The primary aim is to test the causal effect of glucocorticoids on neural reactivity to cannabis cues, and whether this effect depends on co-occurring noradrenergic stimulation. The project will employ a rigorous pharmacological challenge design using hydrocortisone and yohimbine to isolate the effects of the hypothalamic-pituitary-adrenal (HPA) axis and noradrenergic systems. Neural measures of drug cue reactivity and endocannabinoid system activity will be assessed as primary and exploratory outcomes, respectively. The total award amount is $814,252, with a project period from May 1, 2024 to April 30, 2026. The awardee is Auburn University, a prominent public research institution.