Project Grant R21CA318443
- Federal Grant Award Summary The National Cancer Institute (NCI), under the Cancer Biology Research program (CFDA 93.396), awarded a $401,115 Project Grant to the University of Texas Health Science Center at Houston for a two-year research initiative spanning August 1, 2026, through July 31, 2028. The award supports fundamental research investigating the molecular mechanisms by which hepatic Sirtuin 3 (SIRT3) regulates the progression from metabolic dysfunction-associated steatohepatitis (MASH)...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $2.88 million Project Grant award from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393), effective August 5, 2025, through July 31, 2029. This award supports the development of etiology-adjusted precision liver cancer risk prediction tools and resources. The project focuses on developing non-invasive biomarkers and risk assessment strategies...
- Federal Project Grant Award Summary The National Cancer Institute awarded The University of Texas Southwestern Medical Center a $682,969 Project Grant under the Cancer Biology Research program (CFDA 93.396) for the period July 1, 2026 through June 30, 2031. The project, titled "Hormonal Regulation of Myeloid Checkpoints in the Tumor Microenvironment," will deliver fundamental cancer immunology research focused on understanding how hormonal signaling regulates immunosuppressive...
- Federal Project Grant Award Summary The University of Texas MD Anderson Cancer Center received a $421,685 project grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), awarded August 1, 2025, with a completion date of July 31, 2027. This award supports research investigating the LIFR-LCN2 pathway as a novel mechanism of immune suppression in hepatocellular carcinoma (HCC). The research aims to elucidate how loss of LIFR upregulates LCN2, leading to...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $621,121 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), awarded July 10, 2026, with completion scheduled for June 30, 2031. This grant funds fundamental cancer biology research investigating tumor-niche co-evolution mechanisms driving metastatic ovarian cancer (MOVCA) progression and therapeutic resistance. The research integrates...
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $402,011 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) for a five-year research project running from May 1, 2026, through April 30, 2031. The award funds fundamental research investigating the KEAP1-NRF2 (Kelch-like ECH-associated protein 1-Nuclear Factor Erythroid 2-Related Factor 2) redox-sensing pathway and its role in controlling T-cell...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The University of Texas Southwestern Medical Center a $498,732 Project Grant under the Cancer Treatment Research program (CFDA 93.395) effective July 1, 2026, through June 30, 2031. This research initiative will investigate the role of low-density lipoprotein (LDL) uptake in tumor immunity and immunotherapy efficacy, specifically examining how systemic and tumor-local LDL availability influences CD8+ T cell function and...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $687,594 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) effective July 1, 2026, through June 30, 2031. The award supports fundamental research investigating brain metastasis organotropism and therapy response in small cell lung cancer (SCLC). The project delivers preclinical research services including development and...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Texas at Austin a $626,203 Project Grant on July 16, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to investigate the mechanisms linking obesity to prostate cancer progression through DNA structure-induced genetic instability. The research will be conducted through June 30, 2031, and focuses on elucidating how obesity increases mutagenesis at H-DNA sequences—alternative DNA...
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $7.54 million Cancer Centers Support Grant (CCSG, CFDA 93.397) from the National Cancer Institute, awarded September 5, 2025, through August 31, 2030. This grant supports the UT Southwestern Liver Cancer Specialized Program of Research Excellence (SPORE), which assembles a multidisciplinary team of basic, clinical, and translational scientists to develop personalized medical interventions targeting...
The University of Texas Southwestern Medical Center received a $426,828 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), awarded July 20, 2026, with completion targeted for June 30, 2028. The award funds fundamental research investigating the neuro-immune axis in obesity-induced liver cancer progression, specifically examining how disruption of communication between the nervous and immune systems in the liver promotes chronic inflammation and hepatocellular carcinoma (HCC) development. The research deliverables include scientific investigation of how obesity-associated loss of hepatic neural regulation alters macrophage function and results in persistent inflammation, progression of metabolic dysfunction-associated steatotic liver disease (MASLD), and increased HCC susceptibility. The project's primary research products consist of empirical findings from two complementary research aims: (1) definition of how obesity-associated disruption of hepatic neuro-immune communication contributes to liver tumor development using experimental models and human liver specimens; and (2) determination of the immune mechanisms through which neural regulation restrains inflammation and suppresses hepatocarcinogenesis. Deliverables will be generated through mouse model studies enabling investigation of complex neuro-immune interactions within intact liver microenvironments and longitudinal assessment of disease progression. Findings are expected to advance fundamental cancer biology knowledge and inform prevention, detection, and treatment approaches for obesity-driven HCC, consistent with NCI's Cancer Biology Research program objectives.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $426.8k | 7/17/26 |