Project Grant R01CA309809
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $639,514 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) for the period June 1, 2026, through May 31, 2031. This award funds fundamental research to characterize the catalytic mechanism of NVL, an essential AAA+ adenosine triphosphatase (ATPase) required for ribosomal subunit assembly, and to elucidate how benzothiazepinone inhibitors...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $426,828 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), awarded July 20, 2026, with completion targeted for June 30, 2028. The award funds fundamental research investigating the neuro-immune axis in obesity-induced liver cancer progression, specifically examining how disruption of communication between the nervous and immune systems...
- Federal Project Grant Award Summary The National Cancer Institute's Cancer Treatment Research program (CFDA 93.395) awarded a $164,000 Project Grant to The University of Texas MD Anderson Cancer Center, effective September 1, 2025, through August 31, 2027. This award supports research investigating the clonal determinants of platinum/PARP inhibitor (PARPi) cross-resistance in high-grade serous ovarian cancer (HGSOC). The research utilizes a novel somatic mosaic genetically-engineered mouse model...
- Federal Project Grant Award Summary The National Cancer Institute awarded The University of Texas Southwestern Medical Center a $682,969 Project Grant under the Cancer Biology Research program (CFDA 93.396) for the period July 1, 2026 through June 30, 2031. The project, titled "Hormonal Regulation of Myeloid Checkpoints in the Tumor Microenvironment," will deliver fundamental cancer immunology research focused on understanding how hormonal signaling regulates immunosuppressive...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $687,594 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) effective July 1, 2026, through June 30, 2031. The award supports fundamental research investigating brain metastasis organotropism and therapy response in small cell lung cancer (SCLC). The project delivers preclinical research services including development and...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $688,073 Project Grant on June 1, 2026, under the Cancer Biology Research program (CFDA 93.396) to The University of Texas MD Anderson Cancer Center for a five-year project extending through May 31, 2031. This award funds the development of novel computational and molecular archaeology approaches to reconstruct and elucidate the evolutionary history of cancer metastases. The research addresses a critical knowledge gap...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $426,828 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) on May 4, 2026, with a completion date of April 30, 2028. The grant funds investigator-initiated research into JUMONJI KDM5 histone demethylase enzymes and their role in mediating resistance to CDK4/6 inhibitors in estrogen receptor-positive (ER+) breast cancer. The...
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $402,011 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) for a five-year research project running from May 1, 2026, through April 30, 2031. The award funds fundamental research investigating the KEAP1-NRF2 (Kelch-like ECH-associated protein 1-Nuclear Factor Erythroid 2-Related Factor 2) redox-sensing pathway and its role in controlling T-cell...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a $2.64M project grant under the Cancer Biology Research program (CFDA 93.396) to The University of Texas MD Anderson Cancer Center for a four-year study (August 1, 2025 – July 31, 2029) investigating age-related increases in omental metastatic competence in ovarian cancer patients. The research will identify mechanisms by which aging enhances the omentum's susceptibility to cancer cell colonization and develop...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $596,501 Project Grant to The University of Texas Southwestern Medical Center, effective June 20, 2026, through May 31, 2031, under the Cancer Biology Research program (CFDA 93.396). The award supports fundamental research investigating the molecular mechanisms of translocation renal cell carcinoma (TRCC), an aggressive pediatric kidney cancer characterized by chromosomal translocations in microphtalmia (MIT) transcription...
The University of Texas Southwestern Medical Center received a $621,121 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), awarded July 10, 2026, with completion scheduled for June 30, 2031. This grant funds fundamental cancer biology research investigating tumor-niche co-evolution mechanisms driving metastatic ovarian cancer (MOVCA) progression and therapeutic resistance. The research integrates advanced methodologies including clonal barcoding, single-cell RNA sequencing, and in vivo CRISPR screening to trace the evolutionary trajectory of metastatic ovarian cancer cells and characterize niche-adaptive changes. The deliverables include mechanistic studies identifying how tumor cells adapt to their microenvironment during disease progression and chemotherapy treatment, with the ultimate goal of identifying targetable signaling nodes to overcome chemoresistance and inform development of more effective, rationally designed targeted therapies. The two primary research aims generate distinct scientific products: Aim 1 delivers temporal mapping of metastatic ovarian cancer population evolution during chemotherapy and identification of gene-gene interactions promoting dissemination and therapeutic resistance; Aim 2 produces characterization of immune milieu and biophysical niche structures regulating metastasis and treatment response, leveraging in vivo CRISPR screening in syngeneic immunocompetent mouse models to overcome limitations of in vitro and fixed tissue approaches. These research outputs are designed to provide scientific rationale for next-generation therapeutic development in ovarian cancer treatment.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $621.1k | 7/10/26 |