Project Grant R21CA318067
- Federal Project Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded $120,393 to the University of California, Berkeley on May 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop genome editing delivery vehicles capable of amplifying editing efficiencies in vivo. The research focuses on engineering enveloped delivery vehicles (EDVs)—lentivirus-derived lipid vesicles...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a $680,597 Project Grant to The Regents of the University of California, San Francisco under the Cancer Biology Research program (CFDA 93.396) effective April 1, 2026 through March 31, 2031. This five-year award funds genome-wide CRISPR screening research designed to identify G-protein-coupled receptor (GPCR) pathway targets that enhance chimeric antigen receptor (CAR)-T cell therapies for solid tumors. The...
- Federal Grant Award Summary The National Cancer Institute awarded New York University School of Medicine a $595,993 Project Grant (CFDA 93.395: Cancer Treatment Research) effective July 16, 2026, through July 31, 2031, to develop integrated biologic technologies for selective inhibition of intracellular oncoproteins. The project aims to establish a robust platform technology enabling direct and selective manipulation of intracellular driver oncoproteins and their interactions. The research...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Massachusetts General Hospital a $2.86 million Project Grant under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) on September 19, 2025, with completion targeted for August 31, 2029. The award funds development and validation of CAMPEX (CRISPR-Accelerated Molecular Profiling of Extracellular Vesicles), an innovative diagnostic platform designed to advance cancer detection and monitoring through liquid...
- Federal Grant Award Summary The National Cancer Institute awarded The Leland Stanford Junior University a $368,294 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for the period September 1, 2025 through August 31, 2028. This award supports the development of next-generation platforms for interrogating T cell receptor (TCR) specificity to identify and detect tumor antigens at the protein level. The project addresses a critical bottleneck in cancer...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Regents of the University of California, San Francisco a $680,598 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective September 1, 2025, with a completion date of August 31, 2030. The award supports fundamental research focused on decoding the Cullin-5 (CUL5) E3 ubiquitin ligase complex to engineer therapeutic T cells with enhanced durability and sustained effector function. The project...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $421,685 Project Grant to The Regents of the University of California, San Francisco under the Cancer Biology Research program (CFDA 93.396) for research activities spanning August 8, 2025 through July 31, 2027. This award funds a discovery-focused research initiative investigating functional immune niches within the tumor microenvironment (TME) that support effective cancer immunotherapy responses. The primary deliverable...
- Federal Project Grant Award Summary The National Cancer Institute awarded a Project Grant of $418,176.00 to Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) for the period September 1, 2025, through August 31, 2028. This three-year award supports the advanced development and validation of programmable nucleic acid cytometry, a technology designed to isolate and profile rare cell populations from tumors and tissues. Building on the...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded $172,889 to The Regents of the University of California, San Francisco (UCSF) under the Cancer Research Manpower program (CFDA 93.398) on January 12, 2026, with a completion date of March 31, 2027. This Project Grant supports research training and workforce development focused on developing optimized chimeric antigen receptor (CAR) T-cell therapies for acute myeloid leukemia (AML). The funded research employs...
- Federal Project Grant Award Summary The University of California, San Francisco (UCSF) received a $1.476 million Project Grant award dated September 15, 2025, under the Trans-NIH Research Support program (CFDA 93.310) from the National Institutes of Health (NIH) Office of the Director. The award supports a three-year research initiative (completion date: August 31, 2028) titled "Engineering Enhanced Erythropoiesis for Red Blood Cell Disorders," which addresses critical limitations in...
The National Cancer Institute (NCI) awarded J. David Gladstone Institutes a $485,966 Project Grant on July 10, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to support research on engineering targeted delivery vehicles for genome editing in hematopoietic stem cells (HSCs). The award, which extends through June 30, 2028, funds the development and characterization of enveloped delivery vehicles (EDVs)—lentivirally derived lipid vesicles designed to encapsulate CRISPR-Cas9 ribonucleoproteins and display engineered antibody fragments on their surface. These delivery systems are intended to address the clinical challenge of efficiently targeting genome editors to specific cell populations while minimizing off-target effects. The research deliverables focus on defining how antibody fragment presentation on EDVs influences their capacity to target HSCs, a clinically significant population for treating blood and immune disorders including acute myeloid leukemia and myelodysplastic syndromes. The project encompasses two primary aims: quantifying how EDV avidity (ligand density and affinity) affects uptake and genome editing efficiency in human HSCs ex vivo, and evaluating biodistribution and genome editing specificity in humanized mouse models. The work builds upon the institute's existing expertise in EDV development and CRISPR-Cas9 mechanistic biology to optimize the balance between selective HSC targeting and minimization of bystander cell uptake.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $486.0k | 7/10/26 |