Project Grant R21CA313364
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Washington University a $399,829 Project Grant on May 13, 2026, under the Cancer Treatment Research program (CFDA 93.395) to support research into novel dendritic cell-based immunotherapy for solid tumors. The project will deliver mechanistic characterization and preclinical development of AB7H3-TLR4 chimeric antigen receptor (CAR) dendritic cells (DCs)—engineered immune cells designed to overcome tumor immune...
- Federal Grant Award Summary The National Cancer Institute awarded a $399,829 Project Grant to The Washington University (Office of Sponsored Research Services) effective April 1, 2026, through March 31, 2028, under the Cancer Treatment Research program (CFDA 93.395). The project, titled "Rational Design of Next-Generation Engineered T Cells for Enhanced Cancer Immunotherapy," focuses on developing improved chimeric antigen receptor (CAR) T cell therapies by enhancing T cell persistence...
- Federal Grant Award Summary The National Cancer Institute awarded The Washington University a $3.18 million Project Grant under the Cancer Treatment Research program (CFDA 93.395) to investigate the role of natural killer (NK) cells in immune checkpoint therapy (ICT) of cancer. Awarded on September 24, 2025, with a completion date of August 31, 2029, this research project will generate fundamental knowledge about how NK cells may suppress the efficacy of ICT in tumor treatment. The study will...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Washington University a $645,185 Project Grant on May 15, 2026, under the Cancer Treatment Research program (CFDA 93.395) to develop and evaluate an innovative immunotherapy combination approach for glioblastoma treatment. The research will deliver two primary products: (1) mechanistic studies establishing how long-acting Interleukin-7 (IL-7) combined with oncolytic virus therapy improves CD8+ T cell...
- Federal Grant Award Summary The National Cancer Institute awarded a $542,644 Project Grant to The Washington University (Office of Sponsored Research Services) under the Cancer Treatment Research program (CFDA 93.395), effective April 1, 2026, through March 31, 2031. This five-year research initiative focuses on developing radiation-guided antibody-drug conjugates (ADCs) for non-small cell lung cancer (NSCLC) treatment. The research leverages a breakthrough discovery identifying...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Trustees of Columbia University in the City of New York a Project Grant totaling $1,276,947 under the Cancer Treatment Research program (CFDA 93.395) for research on microbial neoantigen cancer vaccines. The award, initiated August 1, 2025, with completion targeted for May 31, 2030, supports fundamental and applied research to improve the therapeutic efficacy and safety of microbial vector-based neoantigen...
- Federal Project Grant Award Summary The National Cancer Institute (NCI), through its Cancer Research Manpower program (CFDA 93.398), awarded The Washington University a Project Grant of $333,504 effective July 1, 2025, through July 31, 2027. This award funds research investigating the dynamics and function of peritoneal myeloid cells during colorectal cancer (CRC) peritoneal dissemination and the implications for immunotherapy. The research aims to elucidate the unique roles of myeloid...
- Federal Grant Award Summary The National Cancer Institute awarded The Washington University a $355,706 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective June 1, 2025, through May 31, 2030. The award funds fundamental research aimed at understanding the role of RAMS11 (RNA Associated with Metastasis 11), a long noncoding RNA (lncRNA), in non-small cell lung cancer (NSCLC) development and progression. The research addresses a critical knowledge gap in cancer biology...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Washington University a Project Grant totaling $2.47 million under the Cancer Biology Research program (CFDA 93.396) on August 18, 2025, with completion targeted for July 31, 2029. This grant supports fundamental research investigating the role of wild-type isocitrate dehydrogenase 1 (WT-IDH1) metabolism in reprogramming the tumor microenvironment of glioblastoma. The research encompasses both in vitro and in...
- Federal Grant Award Summary The National Cancer Institute awarded The Washington University a $641,419 Project Grant on May 7, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to support clinical translation and evaluation of a novel positron emission tomography (PET) theranostic agent for metastatic castrate-resistant prostate cancer (MCRPC). The primary deliverable is the first-in-man clinical imaging study of [77Br]Br-WC-DZ, a bromine-77 ligand targeting...
The National Cancer Institute awarded Washington University a $399,829 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on May 14, 2026, with a completion date of April 30, 2028. This research project targets the enhancement of neoantigen cancer vaccine efficacy by investigating the mechanisms through which Type 1 Regulatory (TR1) CD4 T cells suppress antitumor immune responses. The research deliverables include scientific studies designed to elucidate the role of the EBI3 cytokine subunit and dendritic cell signaling pathways in TR1 cell induction, with the ultimate objective of developing modified vaccine formulations using altered peptide ligands (APLs) that prevent immunosuppressive TR1 cell generation while promoting robust CD8 T cell-mediated tumor rejection. The project will generate research findings, data, and methodological innovations applicable to improving the clinical efficacy of personalized neoantigen-based cancer vaccines. Preliminary studies indicate that neoantigen vaccines containing high-dose APLs with low major histocompatibility complex class II (MHC-II) binding affinity can circumvent TR1 induction and enhance antitumor responses. The research is conducted at Washington University's Office of Sponsored Research Services in St. Louis, Missouri, and is expected to contribute to the broader Cancer Treatment Research program objective of developing improved cancer treatment methods through fundamental and applied laboratory research in biological and molecularly targeted therapies.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $399.8k | 5/14/26 |