Project Grant R01CA298938
- Federal Grant Award Summary The National Cancer Institute awarded The Washington University a $355,706 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective June 1, 2025, through May 31, 2030. The award funds fundamental research aimed at understanding the role of RAMS11 (RNA Associated with Metastasis 11), a long noncoding RNA (lncRNA), in non-small cell lung cancer (NSCLC) development and progression. The research addresses a critical knowledge gap in cancer biology...
- Federal Grant Award Summary The National Cancer Institute awarded The Washington University a Project Grant totaling $399,829 under the Cancer Treatment Research program (CFDA 93.395) for the period April 1, 2026 through March 31, 2028. The award funds research focused on rational design of next-generation engineered T cells to enhance cancer immunotherapy by addressing the critical challenge of limited T cell persistence. The project employs structure-informed protein design to optimize 4-1BB...
- Federal Grant Award Summary The National Cancer Institute awarded a $736,168 Project Grant to Sloan-Kettering Institute for Cancer Research (award date: August 1, 2025; completion date: July 31, 2030) under the Cancer Treatment Research program (CFDA 93.395) to develop novel antibody-drug conjugates (ADCs) and antibody-oligonucleotide conjugates (AOCs) designed to enhance radiotherapy efficacy through antigen-specific radiosensitization. The research focuses on delivering potent DNA damage...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Washington University $101,771 under the Cancer Research Manpower program (CFDA 93.398) for a project grant beginning July 1, 2025, and concluding June 30, 2027. This award supports research investigating the impact of clonal hematopoiesis (CH)—specifically TET2 (Ten-Eleven Translocation 2) mutations in blood-forming cells—on solid tumor development and therapeutic response. The project will deliver fundamental...
- Federal Grant Award Summary The National Cancer Institute awarded The Institute For Cancer Research a $186,000 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on June 23, 2025, with a completion date of May 31, 2027. The award supports pilot and feasibility studies for NN-01-195, a novel tumor-targeted Aurora-A kinase (AURKA) inhibitor developed through a drug conjugate approach. The research involves preclinical evaluation of this chimeric compound, which fuses an...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Washington University in St. Louis a Project Grant totaling $425,088 (Award Date: May 1, 2026; Completion Date: April 30, 2031) under the Cancer Cause and Prevention Research program (CFDA 93.393) to conduct a comparative analysis of lung cancer care and outcomes between Medicare Advantage (MA) and Traditional Medicare (TM) beneficiaries. The research project will leverage large national databases to create...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Washington University a Project Grant totaling $2.47 million under the Cancer Biology Research program (CFDA 93.396) on August 18, 2025, with completion targeted for July 31, 2029. This grant supports fundamental research investigating the role of wild-type isocitrate dehydrogenase 1 (WT-IDH1) metabolism in reprogramming the tumor microenvironment of glioblastoma. The research encompasses both in vitro and in...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Washington University a Project Grant of $427,625 (awarded February 6, 2026; completion date February 5, 2028) under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop radiation-guided theranostic agents for monitoring treatment response in head and neck squamous cell carcinoma (HNSCC). The research leverages radiation-inducible antigens, specifically...
- Federal Project Grant Award Summary The National Cancer Institute (NCI), through its Cancer Research Manpower program (CFDA 93.398), awarded The Washington University a Project Grant of $333,504 effective July 1, 2025, through July 31, 2027. This award funds research investigating the dynamics and function of peritoneal myeloid cells during colorectal cancer (CRC) peritoneal dissemination and the implications for immunotherapy. The research aims to elucidate the unique roles of myeloid...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $615,399 Project Grant to the University of California, Davis under the Cancer Treatment Research program (CFDA 93.395) for the period August 1, 2025, through July 31, 2030. The award supports the development of a transformable nanoparticle (TNP) platform designed to deliver therapeutic peptides and proteins directly to tumor microenvironments on-demand. The TNP technology transforms from nanoparticles to nanofibrils...
The National Cancer Institute awarded The Washington University a $542,644 Project Grant effective April 1, 2026, through March 31, 2031, under the Cancer Treatment Research program (CFDA 93.395). This award supports the development and preclinical evaluation of radiation-guided antibody-drug conjugates (ADCs) targeting Tax-Interacting Protein 1 (TIP1) as a novel therapeutic approach for non-small cell lung cancer (NSCLC). The research leverages a breakthrough discovery that TIP1 is significantly upregulated on NSCLC cells following external beam radiation therapy, enabling targeted delivery of cytotoxic radiosensitizing drugs directly to tumor cells via anti-TIP1 antibodies. The project deliverables encompass two primary research aims: (1) preclinical validation that anti-TIP1 ADC-mediated radiosensitization is independent of patient mutational status through assessment across NSCLC cell lines and patient-derived xenografts, and (2) investigation of mechanisms by which anti-human TIP1 ADCs enhance radiation-induced tumor immunity and improve immunotherapy response. Research will be conducted at The Washington University's Office of Sponsored Research Services Division in St. Louis, Missouri, with the goal of transforming NSCLC treatment by improving therapeutic efficacy and durability of immune checkpoint blockade responses compared to standard cytotoxic chemotherapy approaches.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $542.6k | 3/30/26 |